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Special Issue "Bone Substitute Materials"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 30 April 2018

Special Issue Editor

Guest Editor
Assoc. Prof. Steven J. Eppell

Case Western Reserve University, Department of Biomedical Engineering, Cleveland, United States
Website | E-Mail
Interests: Biomimetic Biomaterial Design and Synthesis, 3D Nanoscale Imaging and Force Measurement

Special Issue Information

Dear Colleagues,

This issue focuses on the design, synthesis and/or evaluation of bone substitute materials. Appropriate submissions use information about the nanoscale structure of natural bone in a way that allows the synthetic material to duplicate biomechanical and/or cellular behavior of the natural system.  Submissions describing attempts to duplicate collagen structures, mineral apatites, ground substance and their hierarchical juxstapositions as found in bone are welcome.   All submissions must clearly connect material composition and/or structure with the desired mechanical and/or biological function of the biomaterial.  Authors are encouraged to include a section in each manuscript devoted to explaining how the materials science and engineering aspects of the work are related to solving an outstanding clinical problem.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.

Assoc. Prof. Steven J. Eppell
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Bone
  • biomaterial
  • collagen
  • mineral
  • ground substance
  • biomechanics
  • remodelling
  • biocompatible
  • osteoblast
  • osteoclast

Published Papers (1 paper)

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Open AccessArticle Impact of Surface Potential on Apatite Formation in Ti Alloys Subjected to Acid and Heat Treatments
Materials 2017, 10(10), 1127; doi:10.3390/ma10101127
Received: 29 August 2017 / Revised: 13 September 2017 / Accepted: 21 September 2017 / Published: 24 September 2017
PDF Full-text (2960 KB) | HTML Full-text | XML Full-text
Titanium metal (Ti) and its alloys are widely used in orthopedic and dental fields. We have previously shown that acid and heat treatment was effective to introduce bone bonding, osteoconduction and osteoinduction on pure Ti. In the present study, acid and heat treatment
[...] Read more.
Titanium metal (Ti) and its alloys are widely used in orthopedic and dental fields. We have previously shown that acid and heat treatment was effective to introduce bone bonding, osteoconduction and osteoinduction on pure Ti. In the present study, acid and heat treatment with or without initial NaOH treatment was performed on typical Ti-based alloys used in orthopedic and dental fields. Dynamic movements of alloying elements were developed, which depended on the kind of treatment and type of alloy. It was found that the simple acid and heat treatment enriched/remained the alloying elements on Ti–6Al–4V, Ti–15Mo–5Zr–3Al and Ti–15Zr–4Nb–4Ta, resulting in neutral surface charges. Thus, the treated alloys did not form apatite in a simulated body fluid (SBF) within 3 days. In contrast, when the alloys were subjected to a NaOH treatment prior to an acid and heat treatment, alloying elements were selectively removed from the alloy surfaces. As a result, the treated alloys became positively charged, and formed apatite in SBF within 3 days. Thus, the treated alloys would be useful in orthopedic and dental fields since they form apatite even in a living body and bond to bone. Full article
(This article belongs to the Special Issue Bone Substitute Materials)

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