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Special Issue "Screening of Bioactive Compounds from Marine Sources"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (4 April 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Elena Ibañez

Foodomics Laboratory, Bioactivity and Food Analysis Department, Institute of Food Science Research (CIAL-CSIC), Nicolás Cabrera 9, Campus UAM Cantoblanco, 28049 Madrid-Spain
Website | E-Mail
Interests: green extraction processes; bioactives; sustainability; biorefinery; agricultural by-products; algae; compressed fluids; advanced analytical techniques
Guest Editor
Dr. Miguel Herrero

Laboratory of Foodomics, Institute of Food Science Research (CIAL, CSIC), Nicolás Cabrera 9, 28049 - Madrid, Spain
Website | E-Mail
Interests: food bioactivity; bioactives extraction from natural sources; foodomics; advanced analytical techniques for food analysis; coupled analytical techniques; comprehensive LCxLC; mass spectrometry

Special Issue Information

Dear Colleagues,               

Marine sources are an unlimited field of research in terms of bioactive compounds that are synthesized. Some of them have demonstrated important biological properties towards the prevention of various diseases including cancer, neurodegenerative diseases, obesity, etc. Current research in the screening of bioactive compounds from marine sources focuses on the design of new extraction processes to isolate the target compounds, the bioprospecting of new unexplored marine sources of bioactive compounds, the chemical characterization of the products and the testing of the different associated bioactivities, among others. The goal of this Marine Drugs Special Issue is to gather the most relevant and new research articles in the field able to outline the progress in this important field.   

Prof. Dr. Elena Ibañez
Dr. Miguel Herrero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive compounds

  • Marine Sources

  • Chemical characterization

  • Green Processes Design

Published Papers (3 papers)

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Research

Open AccessArticle A Marine Isolate of Bacillus pumilus Secretes a Pumilacidin Active against Staphylococcus aureus
Mar. Drugs 2018, 16(6), 180; https://doi.org/10.3390/md16060180
Received: 24 April 2018 / Revised: 9 May 2018 / Accepted: 22 May 2018 / Published: 24 May 2018
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Abstract
Producing antimicrobials is a common adaptive behavior shared by many microorganisms, including marine bacteria. We report that SF214, a marine-isolated strain of Bacillus pumilus, produces at least two different molecules with antibacterial activity: a molecule smaller than 3 kDa active against Staphylococcus
[...] Read more.
Producing antimicrobials is a common adaptive behavior shared by many microorganisms, including marine bacteria. We report that SF214, a marine-isolated strain of Bacillus pumilus, produces at least two different molecules with antibacterial activity: a molecule smaller than 3 kDa active against Staphylococcus aureus and a molecule larger than 10 kDa active against Listeria monocytogenes. We focused our attention on the anti-Staphylococcus molecule and found that it was active at a wide range of pH conditions and that its secretion was dependent on the growth phase, medium, and temperature. A mass spectrometry analysis of the size-fractionated supernatant of SF214 identified the small anti-Staphylococcus molecule as a pumilacidin, a nonribosomally synthesized biosurfactant composed of a mixture of cyclic heptapeptides linked to fatty acids of variable length. The analysis of the SF214 genome revealed the presence of a gene cluster similar to the srfA-sfp locus encoding the multimodular, nonribosomal peptide synthases found in other surfactant-producing bacilli. However, the srfA-sfp cluster of SF214 differed from that present in other surfactant-producing strains of B. pumilus by the presence of an insertion element previously found only in strains of B. safensis. Full article
(This article belongs to the Special Issue Screening of Bioactive Compounds from Marine Sources)
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Open AccessArticle Pressurized Liquid Extraction (PLE) as an Innovative Green Technology for the Effective Enrichment of Galician Algae Extracts with High Quality Fatty Acids and Antimicrobial and Antioxidant Properties
Mar. Drugs 2018, 16(5), 156; https://doi.org/10.3390/md16050156
Received: 4 April 2018 / Revised: 3 May 2018 / Accepted: 8 May 2018 / Published: 10 May 2018
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Abstract
Marine organisms are potentially prolific sources of high qualify fatty acids that represent useful leads in the development of new nutraceutical agents. In this work, we investigated the lipid composition of six algae species from the Northwest of Spain (Ulva intestinalis,
[...] Read more.
Marine organisms are potentially prolific sources of high qualify fatty acids that represent useful leads in the development of new nutraceutical agents. In this work, we investigated the lipid composition of six algae species from the Northwest of Spain (Ulva intestinalis, Ulva lactuca, Fucus vesiculosus, Dictyota dichotoma, Cystoseira baccata and Himanthalia elongata) and compared the antioxidant and antibacterial activity of ethanolic extracts obtained by pressurized liquid extraction (PLE). Furthermore, Fucus vesiculosus (F. vesiculosus) PLE using five solvents of different polarities (hexane, ethyl acetate, acetone, ethanol and ethanol:water 50:50) at three temperatures (80 °C, 120 °C and 160 °C) was investigated. F. vesiculosus ethanolic PLE extract presents considerably higher capacity of inhibiting 50% of DPPH (1,1-diphenyl-2-picryl hydrazyl) (IC50 = 7.17 μg/mL) in comparison with the rest of macroalgae studied. Moreover, the potential antimicrobial activity tested on E. coli and S. aureus shows that F. vesiculosus extract produced the best inhibition (IC50 was 2.24 mg/mL (E. coli) and 1.27 mg/mL (S. aureus)). Furthermore, regarding the different solvents and temperatures used to investigate F. vesiculosus PLE, results showed that this technique using ethyl acetate is a selective method to enrich long chain fatty acids (oleic acid, arachidonic acid and eicosapentaenoic acid) with ω-6/ω-3 ratios close to 2.7. Full article
(This article belongs to the Special Issue Screening of Bioactive Compounds from Marine Sources)
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Open AccessFeature PaperArticle Bioactivity Assessment of Indian Origin—Mangrove Actinobacteria against Candida albicans
Mar. Drugs 2018, 16(2), 60; https://doi.org/10.3390/md16020060
Received: 27 December 2017 / Revised: 6 February 2018 / Accepted: 9 February 2018 / Published: 12 February 2018
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Abstract
Actinobacteria is found to have a potent metabolic activity against pathogens. The present study reveals the assessment of potent antifungal secondary metabolites from actinobacteria isolated from Indian marine mangrove sediments. The samples were collected from the coastal regions of Muthupet, Andaman and the
[...] Read more.
Actinobacteria is found to have a potent metabolic activity against pathogens. The present study reveals the assessment of potent antifungal secondary metabolites from actinobacteria isolated from Indian marine mangrove sediments. The samples were collected from the coastal regions of Muthupet, Andaman and the Nicobar Islands. Identification was carried out using 16S rRNA analysis and biosynthetic genes (Polyketide synthase type I/II and Non-ribosomal peptide synthase) were screened. Actinobacteria were assayed for their antifungal activity against 16 clinical Candida albicans and the compound analysis was performed using gas chromatography-mass spectrometry GC-MS. The 31 actinobacterial strains were isolated and 16S rRNA gene sequencing revealed that this ecosystem is rich on actinobacteria, with Streptomyces as the predominant genus. The PCR based screening of biosynthetic genes revealed the presence of PKS-I in six strains, PKS-II in four strains and NRPS in 11 strains. The isolated actinobacteria VITGAP240 and VITGAP241 (two isolates) were found to have a potential antifungal activity against all the tested C. albicans. GC-MS results revealed that the actinobacterial compounds were belonging to heterocyclic, polyketides and peptides. Overall, the strains possess a wide spectrum of antifungal properties which affords the production of significant bioactive metabolites as potential antibiotics. Full article
(This article belongs to the Special Issue Screening of Bioactive Compounds from Marine Sources)
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