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Special Issue "Marine Biomaterials II, 2017"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 30 October 2017

Special Issue Editor

Guest Editor
Prof. Dr. Hermann Ehrlich

Institute of Experimental Physics, TU Bergakademie Freiberg, Germany
Website | E-Mail
Phone: +00493731 392867
Fax: +0049 3731 394314
Interests: marine biomaterials; biominerals; biocomposites and biomimetics

Special Issue Information

Dear Colleagues,

Recent technological and methodological advances in structural biology, genomics, proteomics, biomineralization, bioinspired materials chemistry, biological assays and biomimetics have resulted in the isolation and practical evaluation of diverse biomaterials. These compounds range in structural class from simple linear peptides to complex biopolymers, bioadhesives, bioelastomers and hierarchically structured biocomposites. There is no doubt that the diversity of biological materials of marine origin is almost equivalent to marine biodiversity, including very special aquatic niches such as in the Arctic and Antarctic seas, or abyssal and hadal zones. According to the generalized classification of biological materials of marine origin, we have chosen the following topics to be covered in the Special Issue:

  • Biomineralized structures and biocomposites of invertebrates origin (skeletal networks, macro- and microscleres, spicules, spines, bristles, cell walls, cyst walls, loricae, etc.)
  • Biomineralized structures and biocomposites of vertebrates origin (bones of whales; fish scales, spines, bones and otoliths; calculi and stones)
  • Non-mineralized structures (bioelastomers such as abductin; cartilage; bioadhesives e.g., byssus and related DOPA-based polymers; biocements and glues)
  • Macromolecular biopolymers (marine polysaccharides of algal origin; chitin, chitosan; conchiolin (periostracum), collagens, hagfish keratins, resilin, gorgonin, spongin, antipathin; marine amphipod silk)
  • Self-made biological materials (tubular structures of marine invertebrates like some protists, foraminifera or worms which are made by co-agglutination of external mineral debris, sand grains or other particles)

Prof. Dr. Hermann Ehrlich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.



  • biominerals
  • biocomposites
  • biomimetics
  • biomaterial
  • biosilica
  • bioelastomers
  • calcification
  • chitin /chitosan
  • collagen
  • corals
  • marine invertebrates
  • spicule

Published Papers (1 paper)

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Open AccessArticle Chitosan Ascorbate Nanoparticles for the Vaginal Delivery of Antibiotic Drugs in Atrophic Vaginitis
Mar. Drugs 2017, 15(10), 319; doi:10.3390/md15100319
Received: 14 September 2017 / Revised: 10 October 2017 / Accepted: 13 October 2017 / Published: 19 October 2017
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The aim of the present work was the development of chitosan ascorbate nanoparticles (CSA NPs) loaded into a fast-dissolving matrix for the delivery of antibiotic drugs in the treatment of atrophic vaginitis. CSA NPs loaded with amoxicillin trihydrate (AX) were obtained by ionotropic
[...] Read more.
The aim of the present work was the development of chitosan ascorbate nanoparticles (CSA NPs) loaded into a fast-dissolving matrix for the delivery of antibiotic drugs in the treatment of atrophic vaginitis. CSA NPs loaded with amoxicillin trihydrate (AX) were obtained by ionotropic gelation in the presence of pentasodium tripolyphosphate (TPP). Different CSA:TPP and CSA:AX weight ratios were considered and their influence on the particle size, polydispersion index and production yield were investigated. CSA NPs were characterized for mucoadhesive, wound healing and antimicrobial properties. Subsequently, CSA NPs were loaded in polymeric matrices, whose composition was optimized using a DoE (Design of Experiments) approach (simplex centroid design). Matrices were obtained by freeze-drying aqueous solutions of three hydrophilic excipients, polyvinylpirrolidone, mannitol and glycin. They should possess a mechanical resistance suitable for the administration into the vaginal cavity and should readily dissolve in the vaginal fluid. In addition to antioxidant properties, due to the presence of ascorbic acid, CSA NPs showed in vitro mucoadhesive, wound healing and antimicrobial properties. In particular, nanoparticles were characterized by an improved antimicrobial activity with respect to a chitosan solution, prepared at the same concentration. The optimized matrix was characterized by mechanical resistance and by the fast release in simulated vaginal fluid of nanoparticles characterized by unchanged size. Full article
(This article belongs to the Special Issue Marine Biomaterials II, 2017)

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Journal Contact

Marine Drugs Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
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