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Special Issue "Selected Papers from the 3rd Sino-Italian Symposium on Bioactive Natural Products & 1st International Forum for Drug Discovery Chemistry"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 28 February 2018

Special Issue Editors

Guest Editor
Prof. Orazio Taglialatela-Scafati

Department of Pharmacy, University of Naples Federico II, Italy
Website | E-Mail
Interests: marine and terrestrial natural products; pharmaceutical biology; stereostructure elucidation; bioactivity
Guest Editor
Professor Huiming Ge

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China
Website | E-Mail
Interests: natural products; natural product biosynthesis and engineering; new bioactive molecule discovery from microbes

Special Issue Information

Dear Colleagues,

China and Italy are both renowned for the leadership in natural product chemistry and the innovative discovery of new medicines from natural sources, founded on a thousand-year-old tradition. The 3rd Sino–Italian Symposium on Bioactive Natural Products (SISBNP) and the 1st International Forum for Drug Discovery Chemistry (IFDDC), sponsored by the Natural Science Foundation of China, will be held, jointly, 13–15 October, 2017, in Nanjing, the capital of six dynasties of Ancient China. This is the third conference of a series that started with the Shanghai (SIMM) conference in 2015, and continued with the Naples conference in 2016.

The aim of such academic events is to share advanced ideas in the field of natural product sciences and to appreciate the relevant breakthroughs that may promote the development of drug discovery chemistry, with an indispensible significance for human survival.

This Marine Drugs Special Issue (http://www.mdpi.com/journal/marinedrugs/special_issues
/SISBNP_IFDDC_2017) will host contributions from the Nanjing conference, with a particular focus on natural products isolated from marine invertebrates and marine microorganisms, potentially useful as biological tools or as lead compounds for the development of new drugs.

We plan to receive submissions from November 2017 until the end of September 2018. Manuscripts will be published on an ongoing basis after being processed.

Prof. Orazio Taglialatela-Scafati
Prof. Huiming Ge
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Sino-Italian Symposium on Bioactive Natural Products
  • Drug discovery
  • Marine invertebrates
  • Marine microorganisms
  • Lead compounds
  • Biological tools

Published Papers (1 paper)

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Research

Open AccessArticle Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island
Mar. Drugs 2017, 15(12), 381; doi:10.3390/md15120381
Received: 3 November 2017 / Revised: 25 November 2017 / Accepted: 1 December 2017 / Published: 6 December 2017
PDF Full-text (551 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Fungi residing in mangroves are considered to be a bank of novel bioactive natural products. In the screening for bioactive metabolites from mangrove-derived fungi, the ethyl acetate extract of the fermentation broth of Aspergillus fumigatus JRJ111048, a fungus isolated from the leaves of
[...] Read more.
Fungi residing in mangroves are considered to be a bank of novel bioactive natural products. In the screening for bioactive metabolites from mangrove-derived fungi, the ethyl acetate extract of the fermentation broth of Aspergillus fumigatus JRJ111048, a fungus isolated from the leaves of the mangrove plant Acrostichum specioum endemic to Hainan island, was found to possess insecticidal activity against Spodoptera litura. Bioactivity-guided isolation lead to the discovery of seven metabolites 17, including one new anhydride derivative aspergide (1), one new lipid amide 11-methyl-11-hydroxyldodecanoic acid amide (2), and five known compounds; α-ethyl glucoside (3), spiculisporic acid B (4), spiculisporic acid C (5), spiculisporic acid (6), and secospiculisporic acid B (7). Their structures were established by NMR spectroscopic and MS analyses, and by comparison of previously reported data. Insecticidal activity against S. litura and antifungal activity of these compounds were investigated. As a result, the new compound 1 showed potent insecticidal activity against newly hatched larvae of S. litura, and compound 4 displayed weak antifungal activity against Candida albicans. Full article
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