Special Issue "Toxicogenomics"

Quicklinks

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (30 April 2011)

Special Issue Editor

Guest Editor
Dr. Chris Vulpe
Agricultural Experiment Station, Nutritional Sciences & Toxicology, 119 Morgan Hall #3104, University of California, Berkeley, CA 94720-3104, USA
Website: http://www.vulpelab.net
E-Mail: vulpe@berkeley.edu

Special Issue Information

Dear Colleagues,

Current toxicity testing protocols are limited in the number of compounds that can be assessed, and so there are a multitude of chemical compounds found in the environment for which there are no toxicity data. Toxicogenomics, the study of the interaction between the genome, proteome or metabolome and adverse biological endpoints due to exposure to toxicants, provides a means to generate toxicity data for a large number of compounds in a short time. Toxicogenomic studies can also provide insight into the modes of toxicity of compounds, and can allow the identification of susceptibility and exposure biomarkers. All such data can be integrated to give an improved assessment of the toxic potential of an untested compound.

This special issue will consider research and review articles concerning any aspects of toxicogenomics. Studies focusing on emerging concerns in toxicology such as nanotoxicology and epigenetic toxicity are particularly encouraged.

Dr. Chris Vulpe
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Keywords

drug discovery
ecotoxicology
ecotoxicogenomics
epigenetic toxicity
pitoxicogenomics
functional toxicogenomics
high-throughput compound screening
nanotoxicology
systems toxicology
toxicity pathways

Published Papers (3 papers)

Meagan M. Fricano, Amy C. Ditewig, Paul M. Jung, Michael J. Liguori, Eric A. G. Blomme and Yi Yang

Article: Global Transcriptomic Profiling Using Small Volumes of Whole Blood: A Cost-Effective Method for Translational Genomic Biomarker Identification in Small Animals

Int. J. Mol. Sci. 2011, 12(4), 2502-2517; doi:10.3390/ijms12042502

Received: 2 March 2011; in revised form: 28 March 2011 / Accepted: 1 April 2011 / Published: 13 April 2011

Show/Hide Abstract | Download PDF Full-text (291 KB) | Download XML Full-text |

Ching-Wei Chang, Frederick A. Beland, Wade M. Hines, James C. Fuscoe, Tao Han and James J. Chen

Article: Identification and Categorization of Liver Toxicity Markers Induced by a Related Pair of Drugs

Int. J. Mol. Sci. 2011, 12(7), 4609-4624; doi:10.3390/ijms12074609

Received: 7 April 2011; in revised form: 25 May 2011 / Accepted: 12 July 2011 / Published: 15 July 2011

Show/Hide Abstract | Download PDF Full-text (387 KB) | Download XML Full-text

Gabriella Fabian, Nora Farago, Liliana Z. Feher, Lajos I. Nagy, Sandor Kulin, Klara Kitajka, Tamas Bito, Vilmos Tubak, Robert L. Katona, Laszlo Tiszlavicz and Laszlo G. Puskas

Article: High-Density Real-Time PCR-Based in Vivo Toxicogenomic Screen to Predict Organ-Specific Toxicity

Int. J. Mol. Sci. 2011, 12(9), 6116-6134; doi:10.3390/ijms12096116

Received: 29 April 2011; in revised form: 24 August 2011 / Accepted: 5 September 2011 / Published: 19 September 2011

Show/Hide Abstract | Download PDF Full-text (385 KB) | Download XML Full-text |

Abstract: Toxicogenomics, based on the temporal effects of drugs on gene expression, is able to predict toxic effects earlier than traditional technologies by analyzing changes in genomic biomarkers that could precede subsequent protein translation and initiation of histological organ damage. In the present study our objective was to extend in vivo toxicogenomic screening from analyzing one or a few tissues to multiple organs, including heart, kidney, brain, liver and spleen. Nanocapillary quantitative real-time PCR (QRT-PCR) was used in the study, due to its higher throughput, sensitivity and reproducibility, and larger dynamic range compared to DNA microarray technologies. Based on previous data, 56 gene markers were selected coding for proteins with different functions, such as proteins for acute phase response, inflammation, oxidative stress, metabolic processes, heat-shock response, cell cycle/apoptosis regulation and enzymes which are involved in detoxification. Some of the marker genes are specific to certain organs, and some of them are general indicators of toxicity in multiple organs. Utility of the nanocapillary QRT-PCR platform was demonstrated by screening different references, as well as discovery of drug-like compounds for their gene expression profiles in different organs of treated mice in an acute experiment. For each compound, 896 QRT-PCR were done: four organs were used from each of the treated four animals to monitor the relative expression of 56 genes. Based on expression data of the discovery gene set of toxicology biomarkers the cardio- and nephrotoxicity of doxorubicin and sulfasalazin, the hepato- and nephrotoxicity of rotenone, dihydrocoumarin and aniline, and the liver toxicity of 2,4-diaminotoluene could be confirmed. The acute heart and kidney toxicity of the active metabolite SN-38 from its less toxic prodrug, irinotecan could be differentiated, and two novel gene markers for hormone replacement therapy were identified, namely fabp4 and pparg, which were down-regulated by estradiol treatment.

Last update: 13 December 2010

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert