Special Issue "Toxicogenomics"
Deadline for manuscript submissions: closed (30 April 2011)
Current toxicity testing protocols are limited in the number of compounds that can be assessed, and so there are a multitude of chemical compounds found in the environment for which there are no toxicity data. Toxicogenomics, the study of the interaction between the genome, proteome or metabolome and adverse biological endpoints due to exposure to toxicants, provides a means to generate toxicity data for a large number of compounds in a short time. Toxicogenomic studies can also provide insight into the modes of toxicity of compounds, and can allow the identification of susceptibility and exposure biomarkers. All such data can be integrated to give an improved assessment of the toxic potential of an untested compound.
This special issue will consider research and review articles concerning any aspects of toxicogenomics. Studies focusing on emerging concerns in toxicology such as nanotoxicology and epigenetic toxicity are particularly encouraged.
Dr. Chris Vulpe
- drug discovery
- epigenetic toxicity
- functional toxicogenomics
- high-throughput compound screening
- systems toxicology
- toxicity pathways