Special Issue "Toxicogenomics"
Deadline for manuscript submissions: closed (30 April 2011)
Dr. Chris Vulpe
Agricultural Experiment Station, Nutritional Sciences & Toxicology, 119 Morgan Hall #3104, University of California, Berkeley, CA 94720-3104, USA
Current toxicity testing protocols are limited in the number of compounds that can be assessed, and so there are a multitude of chemical compounds found in the environment for which there are no toxicity data. Toxicogenomics, the study of the interaction between the genome, proteome or metabolome and adverse biological endpoints due to exposure to toxicants, provides a means to generate toxicity data for a large number of compounds in a short time. Toxicogenomic studies can also provide insight into the modes of toxicity of compounds, and can allow the identification of susceptibility and exposure biomarkers. All such data can be integrated to give an improved assessment of the toxic potential of an untested compound.
This special issue will consider research and review articles concerning any aspects of toxicogenomics. Studies focusing on emerging concerns in toxicology such as nanotoxicology and epigenetic toxicity are particularly encouraged.
Dr. Chris Vulpe
- drug discovery
- epigenetic toxicity
- functional toxicogenomics
- high-throughput compound screening
- systems toxicology
- toxicity pathways
Article: High-Density Real-Time PCR-Based in Vivo Toxicogenomic Screen to Predict Organ-Specific Toxicity
Int. J. Mol. Sci. 2011, 12(9), 6116-6134; doi:10.3390/ijms12096116
Received: 29 April 2011; in revised form: 24 August 2011 / Accepted: 5 September 2011 / Published: 19 September 2011| Download PDF Full-text (385 KB) | View HTML Full-text | Download XML Full-text | Supplementary Files
Article: Identification and Categorization of Liver Toxicity Markers Induced by a Related Pair of Drugs
Int. J. Mol. Sci. 2011, 12(7), 4609-4624; doi:10.3390/ijms12074609
Received: 7 April 2011; in revised form: 25 May 2011 / Accepted: 12 July 2011 / Published: 15 July 2011| Download PDF Full-text (387 KB) | View HTML Full-text | Download XML Full-text
Article: Global Transcriptomic Profiling Using Small Volumes of Whole Blood: A Cost-Effective Method for Translational Genomic Biomarker Identification in Small Animals
Int. J. Mol. Sci. 2011, 12(4), 2502-2517; doi:10.3390/ijms12042502
Received: 2 March 2011; in revised form: 28 March 2011 / Accepted: 1 April 2011 / Published: 13 April 2011| Download PDF Full-text (291 KB) | View HTML Full-text | Download XML Full-text | Supplementary Files
Last update: 26 February 2014