Topical Collection "Radiation Toxicity in Cells"

Quicklinks

A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Molecular Toxicology".

Editor

Collection Editor
Dr. Terrence Piva
School of Medical Sciences, RMIT University, PO Box 71 Bundoora, Victoria 3083, Australia
Website: http://www.rmit.edu.au/staff/terry-piva
E-Mail: terry.piva@rmit.edu.au
Phone: Office +61 3 9925 6503; Lab 9925 7278
Fax: +61 3 9925 7063
Interests: cell death; photobiology; photoimmunology; skin cancer; enzymology; cell metabolism; oxidative stress; cancer metabolism; cell signalling; cytokines; inflammation; enzyme kinetics; metal oxide nanoparticles; sunscreens

Topical Collection Information

Dear Colleagues,

Life forms on the planet are exposed to different forms of radiation. Such radiation may be emitted from the sun, such as X-rays, radio waves, and visible, ultraviolet or infrared light. Radiation may also come from other natural sources, such as α-, β- or γ-radiation.  Concern has also been raised about the effects of exposure to microwaves, naturally occurring radioactivity, and heat (thermal radiation).  The mechanisms by which these forms of radiation affect cell function differ considerably, but high levels of exposure can result in cell death, and long-term exposure is known to cause a range of cancers.

This issue will look at the cytotoxic effects of radiation on living systems; studies will range from those concerning cultured cells to those discussing population and epidemiology.   While emphasis will be placed on radiation-induced cytotoxicity, studies discussing radiation’s connections with DNA damage, intracellular signaling pathways, caspase activation, membrane damage, ROS/RNS production, gene activation, organelle dysfunction, and animal and epidemiological studies are also encouraged.  Reviews of the mechanisms involved in the cytotoxic effects of electromagnetic radiation are welcomed, as well as studies discussing the effects of long-term human exposure to these forms of radiation.  I encourage you to submit a manuscript to this issue so as to help shed further “light” on the lethal effects that radiation has on cells and individuals.

Prof. Dr. Terrence Piva
Collection Editor

Manuscript Submission Information

Manuscripts for the topical collection can be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on this website. The topical collection considers regular research articles, short communications and review articles. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Keywords

  • radiation
  • ultraviolet light
  • X-rays
  • γ radiation
  • microwaves
  • cell death pathways
  • DNA damage
  • cell membrane
  • ROS
  • signaling pathways
  • epidemiology studies
  • animal studies

Published Papers (31 papers)

Download All Papers
Sort by:

2015  ( 1 paper )


2014  ( 7 papers )


2013  ( 23 papers )


2015
by , , , , ,  and
Int. J. Mol. Sci. 2015, 16(3), 5789-5802; doi:10.3390/ijms16035789
Received: 15 January 2015 / Revised: 25 February 2015 / Accepted: 4 March 2015 / Published: 12 March 2015
Show/Hide Abstract | PDF Full-text (1299 KB)
abstract graphic

2014
by ,  and
Int. J. Mol. Sci. 2015, 16(1), 68-90; doi:10.3390/ijms16010068
Received: 20 November 2014 / Accepted: 17 December 2014 / Published: 23 December 2014
Show/Hide Abstract | PDF Full-text (2272 KB) | HTML Full-text | XML Full-text

by , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(11), 21419-21432; doi:10.3390/ijms151121419
Received: 10 September 2014 / Revised: 31 October 2014 / Accepted: 4 November 2014 / Published: 19 November 2014
Show/Hide Abstract | PDF Full-text (1212 KB) | HTML Full-text | XML Full-text

by , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(11), 19777-19790; doi:10.3390/ijms151119777
Received: 27 May 2014 / Revised: 24 October 2014 / Accepted: 27 October 2014 / Published: 30 October 2014
Show/Hide Abstract | PDF Full-text (1829 KB) | HTML Full-text | XML Full-text

by , , , ,  and
Int. J. Mol. Sci. 2014, 15(10), 18919-18940; doi:10.3390/ijms151018919
Received: 21 August 2014 / Revised: 1 October 2014 / Accepted: 8 October 2014 / Published: 20 October 2014
Show/Hide Abstract | PDF Full-text (3377 KB) | HTML Full-text | XML Full-text | Supplementary Files

by , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 11555-11565; doi:10.3390/ijms150711555
Received: 7 May 2014 / Revised: 20 June 2014 / Accepted: 24 June 2014 / Published: 27 June 2014
Show/Hide Abstract | Cited by 1 | PDF Full-text (1085 KB) | HTML Full-text | XML Full-text

by , , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(2), 2157-2171; doi:10.3390/ijms15022157
Received: 18 November 2013 / Revised: 30 December 2013 / Accepted: 16 January 2014 / Published: 29 January 2014
Show/Hide Abstract | Cited by 1 | PDF Full-text (503 KB) | HTML Full-text | XML Full-text
abstract graphic

by ,  and
Int. J. Mol. Sci. 2014, 15(1), 927-943; doi:10.3390/ijms15010927
Received: 21 October 2013 / Revised: 26 December 2013 / Accepted: 31 December 2013 / Published: 10 January 2014
Show/Hide Abstract | Cited by 3 | PDF Full-text (465 KB) | HTML Full-text | XML Full-text

2013
by , , ,  and
Int. J. Mol. Sci. 2013, 14(12), 23791-23800; doi:10.3390/ijms141223791
Received: 8 October 2013 / Revised: 20 November 2013 / Accepted: 25 November 2013 / Published: 5 December 2013
Show/Hide Abstract | PDF Full-text (401 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2013, 14(11), 22678-22696; doi:10.3390/ijms141122678
Received: 9 October 2013 / Revised: 1 November 2013 / Accepted: 6 November 2013 / Published: 18 November 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (408 KB) | HTML Full-text | XML Full-text

by , , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(11), 22449-22461; doi:10.3390/ijms141122449
Received: 4 September 2013 / Revised: 25 October 2013 / Accepted: 30 October 2013 / Published: 14 November 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (801 KB) | HTML Full-text | XML Full-text

by , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(10), 19618-19635; doi:10.3390/ijms141019618
Received: 26 June 2013 / Revised: 9 September 2013 / Accepted: 13 September 2013 / Published: 27 September 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (2141 KB) | HTML Full-text | XML Full-text | Supplementary Files

by , , , , ,  and
Int. J. Mol. Sci. 2013, 14(9), 18078-18092; doi:10.3390/ijms140918078
Received: 24 June 2013 / Revised: 21 August 2013 / Accepted: 26 August 2013 / Published: 4 September 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (537 KB) | HTML Full-text | XML Full-text

by , , , ,  and
Int. J. Mol. Sci. 2013, 14(9), 17881-17896; doi:10.3390/ijms140917881
Received: 17 June 2013 / Revised: 2 August 2013 / Accepted: 7 August 2013 / Published: 2 September 2013
Show/Hide Abstract | Cited by 9 | PDF Full-text (755 KB) | HTML Full-text | XML Full-text

by , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(9), 17525-17535; doi:10.3390/ijms140917525
Received: 24 June 2013 / Revised: 14 August 2013 / Accepted: 21 August 2013 / Published: 27 August 2013
Show/Hide Abstract | PDF Full-text (266 KB) | HTML Full-text | XML Full-text
abstract graphic

by  and
Int. J. Mol. Sci. 2013, 14(8), 17029-17054; doi:10.3390/ijms140817029
Received: 9 July 2013 / Revised: 5 August 2013 / Accepted: 9 August 2013 / Published: 19 August 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (1853 KB) | HTML Full-text | XML Full-text

by , ,  and
Int. J. Mol. Sci. 2013, 14(8), 16943-16957; doi:10.3390/ijms140816943
Received: 24 June 2013 / Revised: 1 August 2013 / Accepted: 5 August 2013 / Published: 16 August 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (353 KB) | HTML Full-text | XML Full-text | Supplementary Files
abstract graphic

by ,  and
Int. J. Mol. Sci. 2013, 14(8), 15931-15958; doi:10.3390/ijms140815931
Received: 17 June 2013 / Revised: 19 July 2013 / Accepted: 22 July 2013 / Published: 31 July 2013
Show/Hide Abstract | Cited by 7 | PDF Full-text (446 KB) | HTML Full-text | XML Full-text

by , , ,  and
Int. J. Mol. Sci. 2013, 14(8), 15810-15826; doi:10.3390/ijms140815810
Received: 6 June 2013 / Revised: 15 July 2013 / Accepted: 22 July 2013 / Published: 30 July 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (1841 KB) | HTML Full-text | XML Full-text
abstract graphic

by  and
Int. J. Mol. Sci. 2013, 14(8), 15695-15723; doi:10.3390/ijms140815695
Received: 30 May 2013 / Revised: 15 July 2013 / Accepted: 17 July 2013 / Published: 29 July 2013
Show/Hide Abstract | Cited by 4 | PDF Full-text (372 KB) | HTML Full-text | XML Full-text

by  and
Int. J. Mol. Sci. 2013, 14(8), 15260-15285; doi:10.3390/ijms140815260
Received: 17 June 2013 / Revised: 27 June 2013 / Accepted: 1 July 2013 / Published: 24 July 2013
Show/Hide Abstract | Cited by 7 | PDF Full-text (693 KB) | HTML Full-text | XML Full-text

by , , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 15017-15028; doi:10.3390/ijms140715017
Received: 13 June 2013 / Revised: 8 July 2013 / Accepted: 11 July 2013 / Published: 18 July 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (253 KB) | HTML Full-text | XML Full-text

by , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14974-14995; doi:10.3390/ijms140714974
Received: 5 March 2013 / Revised: 25 June 2013 / Accepted: 1 July 2013 / Published: 17 July 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (679 KB) | HTML Full-text | XML Full-text

by , , , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14105-14118; doi:10.3390/ijms140714105
Received: 3 May 2013 / Revised: 3 June 2013 / Accepted: 21 June 2013 / Published: 8 July 2013
Show/Hide Abstract | Cited by 10 | PDF Full-text (768 KB) | HTML Full-text | XML Full-text

by , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14119-14135; doi:10.3390/ijms140714119
Received: 25 May 2013 / Revised: 18 June 2013 / Accepted: 25 June 2013 / Published: 8 July 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (2381 KB) | HTML Full-text | XML Full-text

by , ,  and
Int. J. Mol. Sci. 2013, 14(7), 14024-14063; doi:10.3390/ijms140714024
Received: 8 May 2013 / Revised: 14 June 2013 / Accepted: 17 June 2013 / Published: 5 July 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (534 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , , , , , ,  and
Int. J. Mol. Sci. 2013, 14(7), 13719-13726; doi:10.3390/ijms140713719
Received: 5 June 2013 / Revised: 15 June 2013 / Accepted: 19 June 2013 / Published: 1 July 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (288 KB) | HTML Full-text | XML Full-text

by , ,  and
Int. J. Mol. Sci. 2013, 14(6), 12222-12248; doi:10.3390/ijms140612222
Received: 25 April 2013 / Revised: 18 May 2013 / Accepted: 24 May 2013 / Published: 7 June 2013
Show/Hide Abstract | Cited by 17 | PDF Full-text (956 KB) | HTML Full-text | XML Full-text

by , ,  and
Int. J. Mol. Sci. 2013, 14(6), 11795-11815; doi:10.3390/ijms140611795
Received: 13 March 2013 / Revised: 17 May 2013 / Accepted: 24 May 2013 / Published: 3 June 2013
Show/Hide Abstract | Cited by 3 | PDF Full-text (480 KB) | HTML Full-text | XML Full-text

by
Int. J. Mol. Sci. 2013, 14(5), 9099-9110; doi:10.3390/ijms14059099
Received: 5 March 2013 / Revised: 19 April 2013 / Accepted: 22 April 2013 / Published: 25 April 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (368 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2013, 14(2), 3773-3785; doi:10.3390/ijms14023773
Received: 9 January 2013 / Revised: 29 January 2013 / Accepted: 6 February 2013 / Published: 8 February 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (270 KB) | HTML Full-text | XML Full-text | Supplementary Files

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: TP53INP1 Gene is Implicated in Radiation-Induced Senescence
Authors:
Nikolett Sándor, Boglárka Schilling Tóth, Enikő Kis, Géza Sáfrány, Hargita Hegyesi
Affiliation:
Division of Molecular Radiobiology and Biodosimetry, F. Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Anna 5, Budapest, 1221 Hungary
Abstract:
Background and Purpose: Tumor protein 53-induced nuclear protein-1 (TP53INP1) encodes two nuclear protein isoforms (TP53INP1α and TP53INP1β) and transcription is activated by p53. Overexpression of TP53INP1 promotes apoptosis and cell cycle arrest in different tumor cell lines. Therefore, TP53INP1 appears as a key element in p53-mediated cell death and cell cycle arrest, induced by cellular stress. Moreover, it was shown that TP53INP1 interacted with p53 and these interactions modified the transcriptional activity of p53 on several target genes such as CDKN1A, PIG-3 and MDM2. The objective of this study was to assess whether TP53INP1 plays a functional role in regulating cellular responses to IR. Methods: F11hTERT (telomerase immortalized) human fibroblast cells were used in the study. To investigate the role of TP53INP1 in radiation response the gene was silenced by the stable transfection of shRNAs using lentiviral vectors. Radiation induced direct and bystander effects were assessed by following survival using colony-forming assay and by investigating mitochondrial DNA deletions by real-time PCR. Alterations in cell cycle distribution were analyzed by flow cytometry, while radiation-induced senescence was studied with SA-β-Gal staining. Autophagy changes were measured by Acridine Orange staining and the expression of TP53INP1, GDF-15, GADD45A and CDKN1A was measured by real-time PCR. Results: We demonstrate here radiation induced dose dependent expressional changes of TP53INP1 in both irradiated and bystander fibroblast cells. We established stable fibroblast cell lines where the expression of TP53INP1 was constitutively knocked-down by RNA interference. TP53INP1 was required for IR induced maximal elevation of CDKN1A and GDF-15 expressions. Likewise, autophagy and senescence was deregulated following irradiation in the absence of TP53INP1. TP53INP1 deficient cells showed resistance of the G2-delay, and the proliferation rate was higher compared with wild type F11hTERTcells. Finally, we showed that TP53INP1 proficiency is important for clonogenic survival after radiation. Conclusions: These data reveal novel functional roles for TP53INP1 in cell cycle, survival and responses to IR. Taken together, we concluded that autophagy impairment induces premature senescence through a TP53INP1-dependent manner in primary human fibroblasts.

Type of Paper: Review
Title:
Cellular pathways involved in radiation toxicity and protection
Authors:
Patrick Maier
Abstract:
During the last decades improvements in planning and application of radiotherapy in combination with surgery and chemotherapy resulted in increased survival rates of tumour patients. However, the success of radiotherapy is impaired by two reasons: firstly radioresistance of tumour cells and secondly radiation-induced damage of normal tissue cells located in the field of ionizing radiation. These limitations demand the development of drugs for either radiosensitisation of tumour cells or radioprotection of normal tissue cells. For this reason, in order to identify targets the detailed understanding of the cellular pathways involved in radiation response is an absolute requirement. The most important pathways of radioresponse and several proteins as targets for radiosensitisation or radioprotection will be described in this review.

Type of Paper: Review
Title:
Molecular, cellular and functional effects of radiation-induced brain injury: a review
Authors:
M. Adamkov, S. Balentova
Abstract:
Radiation therapy is the most effective non-surgical treatment of primary brain tumors and metastases. Preclinical studies have provided valuable insights into pathogenesis of radiation-induced injury to the central nervous system. Radiation-induced brain injury can damage the neuronal, glial and vascular compartments of the brain and may lead to molecular, cellular and functional changes. Given its central role in memory and adult neurogenesis, the majority of studies have focused on the hippocampus. These findings have been interpreted to suggest that the hippocampal avoidance in cranial radiotherapy will prevent radiation-induced cognitive impairment of patients. Multiple rodent studies have shown that this problem is more complex that was previously thought. Regarding the fact, that radiation-induced cognitive impairment reflects both hippocampal and non-hippocampal compartments, there is a critical importance to investigate the molecular, cellular and functional modifications in various brain regions as well as their integration at clinically relevant doses and schedules. Our purpose is to provide a literature overview and our published results in order to help a translation of preclinical findings to the clinical practice, with aim to improve the quality of life in patients with brain tumors.

Last update: 27 March 2015

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert