Special Issue "Programmed Cell Death and Apoptosis 2013"
Deadline for manuscript submissions: 25 December 2013
Prof. Dr. Anthony Lemarié
Department of Experimental Therapeutics, Inserm U1037 Toulouse Cancer Research Center & Institut Claudius Regaud, 20-24 rue du pont St Pierre, 31052 Toulouse cedex, France
Interests: cell death; apoptosis; cellular differentiation; cellular and mitochondrial metabolism; cellular and mitochondrial homoeostasis; oxidative stress; cancer; cancer stem cells; glioma; radiotherapy & radioresistance
Apoptosis is considered as an essential physiological process in eukaryotes for development, tissue homeostasis, wound healing or immune response. Moreover, apoptosis appears as a key player in physiopathological deregulations, since sustained apoptotic cell death characterizes ischemic and degenerative diseases as well as toxicological responses and since impaired cell death confers to cells and tissues a hyperproliferative phenotype as observed in cancer cells or autoimmune diseases. This special issue is dedicated to bring to light some recent developments in the cell death area and to further present some comprehensive reviews on specific “hot” spots in the apoptotic field. In particular, it is of major interest to present the different types of programmed cell death, such as apoptosis, autophagic cell death, necroptosis and secondary necrosis, mitotic catastrophe or senescence and to depict their specific mechanisms and crossovers. The physiopathological context of each process is of particular importance. In addition, the different upstream early events leading to cell death signalling remain to be fully deciphered, notably the role of oxidative stress, ionic homeostasis, metabolic stress signals (e.g. hypoxia), DNA damages and microRNAs.
Concerning apoptosis, several aspects have to be addressed as the dependency on the caspase proteases, the involvement of extrinsic (death receptors) and intrinsic (mitochondrial) pathways and the role of the endoplasmic reticulum pathway. Finally, it would be of great interest to focus on the pro-survival vs pro-apoptotic regulation in tumour cells and during anticancer treatments (either chemo or radiotherapy), particularly towards several emerging targets such as cancer stem cells or circulating cancer cells.
Research articles, review articles as well as communications are invited.
Similar Special Issue could be found in the following:
“Programmed Cell Death and Apoptosis”
Prof. Dr. Anthony Lemarié
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- autophagic cell death
- cancer cell death
- caspase-dependent and independent apoptosis
- cellular and mitochondrial homeostasis
- cell death signalling
- mitochondrial and death receptor pathways
- mitotic catastrophe
- oxidative stress and antioxidants
- programmed cell death
Article: Early Exercise Protects against Cerebral Ischemic Injury through Inhibiting Neuron Apoptosis in Cortex in Rats
Int. J. Mol. Sci. 2013, 14(3), 6074-6089; doi:10.3390/ijms14036074
Received: 14 January 2013; in revised form: 3 February 2013 / Accepted: 28 February 2013 / Published: 15 March 2013| Download PDF Full-text (1787 KB) | Download XML Full-text
Article: Characterization of Apoptosis Induced by Emodin and Related Regulatory Mechanisms in Human Neuroblastoma Cells
Int. J. Mol. Sci. 2013, 14(10), 20139-20156; doi:10.3390/ijms141020139
Received: 1 July 2013; in revised form: 26 September 2013 / Accepted: 26 September 2013 / Published: 9 October 2013| Download PDF Full-text (1117 KB) | Download XML Full-text
Article: Synthetic Resveratrol Analogue, 3,3',4,4',5,5'-Hexahydroxy-trans-Stilbene, Accelerates Senescence in Peritoneal Mesothelium and Promotes Senescence-Dependent Growth of Gastrointestinal Cancers
Int. J. Mol. Sci. 2013, 14(11), 22483-22498; doi:10.3390/ijms141122483
Received: 26 August 2013; in revised form: 18 October 2013 / Accepted: 1 November 2013 / Published: 14 November 2013| Download PDF Full-text (761 KB)
Communication: Identification of Novel Pepper Genes Involved in Bax- or INF1-Mediated Cell Death Responses by High-Throughput Virus-Induced Gene Silencing
Int. J. Mol. Sci. 2013, 14(11), 22782-22795; doi:10.3390/ijms141122782
Received: 24 September 2013; in revised form: 11 November 2013 / Accepted: 11 November 2013 / Published: 19 November 2013| Download PDF Full-text (420 KB) | Supplementary Files
Review: Mevalonate Kinase Deficiency and Neuroinflammation: Balance between Apoptosis and Pyroptosis
Int. J. Mol. Sci. 2013, 14(12), 23274-23288; doi:10.3390/ijms141223274
Received: 22 September 2013; in revised form: 8 November 2013 / Accepted: 13 November 2013 / Published: 26 November 2013| Download PDF Full-text (388 KB)
Article: Bone Morphogenetic Protein-7 Ameliorates Cerebral Ischemia and Reperfusion Injury via Inhibiting Oxidative Stress and Neuronal Apoptosis
Int. J. Mol. Sci. 2013, 14(12), 23441-23453; doi:10.3390/ijms141223441
Received: 21 September 2013; in revised form: 12 November 2013 / Accepted: 19 November 2013 / Published: 28 November 2013| Download PDF Full-text (536 KB)
Last update: 19 April 2013