Special Issue "Programmed Cell Death and Apoptosis"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology".

Deadline for manuscript submissions: closed (31 March 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Anthony Lemarié
Department of Experimental Therapeutics, Inserm U1037 Toulouse Cancer Research Center & Institut Claudius Regaud, 20-24 rue du pont St Pierre, 31052 Toulouse cedex, France
Website: http://eng.claudiusregaud.fr/Research/Fundamental-Research/UMR-1037/Equipe-11-radioresistance-tumorale-des-voies-de-signalisation-a-l-essai-clinique
E-Mail: lemarie.anthony@claudiusregaud.fr
Interests: cell death; apoptosis; cellular differentiation; cellular and mitochondrial metabolism; cellular and mitochondrial homoeostasis; oxidative stress; cancer; cancer stem cells; glioma; radiotherapy & radioresistance

Special Issue Information

Dear Colleagues,

Apoptosis is considered as an essential physiological process in eukaryotes for development, tissue homeostasis, wound healing or immune response. Moreover, apoptosis appears as a key player in physiopathological deregulations, since sustained apoptotic cell death characterizes ischemic and degenerative diseases as well as toxicological responses and since impaired cell death confers to cells and tissues a hyperproliferative phenotype as observed in cancer cells or autoimmune diseases.

This special issue is dedicated to bring to light some recent developments in the cell death area and to further present some comprehensive reviews on specific “hot” spots in the apoptotic field. In particular, it is of major interest to present the different types of programmed cell death, such as apoptosis, autophagic cell death, necroptosis and secondary necrosis, mitotic catastrophe or senescence and to depict their specific mechanisms and crossovers. The physiopathological context of each process is of particular importance. In addition, the different upstream early events leading to cell death signalling remain to be fully deciphered, notably the role of oxidative stress, ionic homeostasis, metabolic stress signals (e.g. hypoxia), DNA damages and microRNAs.

Concerning apoptosis, several aspects have to be addressed as the dependency on the caspase proteases, the involvement of extrinsic (death receptors) and intrinsic (mitochondrial) pathways and the role of the endoplasmic reticulum pathway. Finally, it would be of great interest to focus on the pro-survival vs pro-apoptotic regulation in tumour cells and during anticancer treatments (either chemo or radiotherapy), particularly towards several emerging targets such as cancer stem cells or circulating cancer cells.

Prof. Dr. Anthony Lemarié
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Published Papers:

Published papers in this issue can be found at http://www.mdpi.com/journal/ijms/special_issues/pcd-apoptosis.

Keywords

  • apoptosis
  • autophagic cell death
  • cancer cell death
  • caspase-dependent and independent apoptosis
  • cellular and mitochondrial homeostasis
  • cell death signalling
  • mitochondrial and death receptor pathways
  • mitotic catastrophe
  • oxidative stress and antioxidants
  • programmed cell death

Published Papers (40 papers)

Int. J. Mol. Sci. 2014, 15(4), 6657-6673; doi:10.3390/ijms15046657
Received: 24 January 2014; in revised form: 4 April 2014 / Accepted: 8 April 2014 / Published: 17 April 2014
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Int. J. Mol. Sci. 2014, 15(4), 5388-5409; doi:10.3390/ijms15045388
Received: 7 February 2014; in revised form: 7 March 2014 / Accepted: 20 March 2014 / Published: 27 March 2014
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Int. J. Mol. Sci. 2014, 15(4), 5304-5322; doi:10.3390/ijms15045304
Received: 14 November 2013; in revised form: 7 February 2014 / Accepted: 14 March 2014 / Published: 26 March 2014
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Int. J. Mol. Sci. 2014, 15(3), 4977-4993; doi:10.3390/ijms15034977
Received: 3 February 2014; in revised form: 27 February 2014 / Accepted: 12 March 2014 / Published: 20 March 2014
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Int. J. Mol. Sci. 2014, 15(3), 4356-4392; doi:10.3390/ijms15034356
Received: 20 December 2013; in revised form: 7 February 2014 / Accepted: 21 February 2014 / Published: 12 March 2014
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Int. J. Mol. Sci. 2014, 15(3), 4318-4332; doi:10.3390/ijms15034318
Received: 22 December 2013; in revised form: 10 February 2014 / Accepted: 26 February 2014 / Published: 11 March 2014
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Int. J. Mol. Sci. 2014, 15(3), 3952-3969; doi:10.3390/ijms15033952
Received: 17 January 2014; in revised form: 20 February 2014 / Accepted: 26 February 2014 / Published: 5 March 2014
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Int. J. Mol. Sci. 2014, 15(3), 3816-3833; doi:10.3390/ijms15033816
Received: 12 December 2013; in revised form: 30 January 2014 / Accepted: 6 February 2014 / Published: 3 March 2014
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Int. J. Mol. Sci. 2014, 15(3), 3746-3767; doi:10.3390/ijms15033746
Received: 23 December 2013; in revised form: 10 February 2014 / Accepted: 19 February 2014 / Published: 3 March 2014
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Int. J. Mol. Sci. 2014, 15(3), 3403-3431; doi:10.3390/ijms15033403
Received: 18 December 2013; in revised form: 22 January 2014 / Accepted: 14 February 2014 / Published: 25 February 2014
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Int. J. Mol. Sci. 2014, 15(2), 3145-3153; doi:10.3390/ijms15023145
Received: 6 January 2014; in revised form: 10 February 2014 / Accepted: 13 February 2014 / Published: 21 February 2014
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Int. J. Mol. Sci. 2014, 15(2), 2672-2694; doi:10.3390/ijms15022672
Received: 25 December 2013; in revised form: 10 February 2014 / Accepted: 11 February 2014 / Published: 17 February 2014
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Int. J. Mol. Sci. 2014, 15(2), 2660-2671; doi:10.3390/ijms15022660
Received: 8 November 2013; in revised form: 3 January 2014 / Accepted: 13 February 2014 / Published: 17 February 2014
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Int. J. Mol. Sci. 2014, 15(2), 2494-2516; doi:10.3390/ijms15022494
Received: 30 December 2013; in revised form: 31 January 2014 / Accepted: 7 February 2014 / Published: 13 February 2014
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Int. J. Mol. Sci. 2014, 15(2), 2172-2190; doi:10.3390/ijms15022172
Received: 17 November 2013; in revised form: 25 December 2013 / Accepted: 23 January 2014 / Published: 29 January 2014
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Int. J. Mol. Sci. 2014, 15(2), 1983-2002; doi:10.3390/ijms15021983
Received: 23 October 2013; in revised form: 20 January 2014 / Accepted: 22 January 2014 / Published: 27 January 2014
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Int. J. Mol. Sci. 2014, 15(1), 1538-1553; doi:10.3390/ijms15011538
Received: 9 December 2013; in revised form: 21 December 2013 / Accepted: 13 January 2014 / Published: 21 January 2014
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Int. J. Mol. Sci. 2014, 15(1), 484-503; doi:10.3390/ijms15010484
Received: 10 October 2013; in revised form: 12 December 2013 / Accepted: 16 December 2013 / Published: 2 January 2014
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Int. J. Mol. Sci. 2013, 14(12), 24742-24754; doi:10.3390/ijms141224742
Received: 24 September 2013; in revised form: 3 November 2013 / Accepted: 4 November 2013 / Published: 18 December 2013
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Int. J. Mol. Sci. 2013, 14(12), 24656-24669; doi:10.3390/ijms141224656
Received: 1 September 2013; in revised form: 5 December 2013 / Accepted: 9 December 2013 / Published: 18 December 2013
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Int. J. Mol. Sci. 2013, 14(12), 23441-23453; doi:10.3390/ijms141223441
Received: 21 September 2013; in revised form: 12 November 2013 / Accepted: 19 November 2013 / Published: 28 November 2013
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Int. J. Mol. Sci. 2013, 14(12), 23274-23288; doi:10.3390/ijms141223274
Received: 22 September 2013; in revised form: 8 November 2013 / Accepted: 13 November 2013 / Published: 26 November 2013
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Int. J. Mol. Sci. 2013, 14(11), 22782-22795; doi:10.3390/ijms141122782
Received: 24 September 2013; in revised form: 11 November 2013 / Accepted: 11 November 2013 / Published: 19 November 2013
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Int. J. Mol. Sci. 2013, 14(11), 22483-22498; doi:10.3390/ijms141122483
Received: 26 August 2013; in revised form: 18 October 2013 / Accepted: 1 November 2013 / Published: 14 November 2013
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Int. J. Mol. Sci. 2013, 14(10), 20139-20156; doi:10.3390/ijms141020139
Received: 1 July 2013; in revised form: 26 September 2013 / Accepted: 26 September 2013 / Published: 9 October 2013
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Int. J. Mol. Sci. 2013, 14(3), 6074-6089; doi:10.3390/ijms14036074
Received: 14 January 2013; in revised form: 3 February 2013 / Accepted: 28 February 2013 / Published: 15 March 2013
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Int. J. Mol. Sci. 2013, 14(1), 177-190; doi:10.3390/ijms14010177
Received: 30 July 2012; in revised form: 6 November 2012 / Accepted: 10 December 2012 / Published: 21 December 2012
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Int. J. Mol. Sci. 2012, 13(12), 16472-16488; doi:10.3390/ijms131216472
Received: 22 October 2012; in revised form: 23 November 2012 / Accepted: 27 November 2012 / Published: 4 December 2012
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Int. J. Mol. Sci. 2012, 13(11), 13911-13925; doi:10.3390/ijms131113911
Received: 24 September 2012; in revised form: 25 October 2012 / Accepted: 25 October 2012 / Published: 29 October 2012
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Int. J. Mol. Sci. 2012, 13(9), 11923-11940; doi:10.3390/ijms130911923
Received: 28 June 2012; in revised form: 5 September 2012 / Accepted: 11 September 2012 / Published: 20 September 2012
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Int. J. Mol. Sci. 2012, 13(8), 9877-9892; doi:10.3390/ijms13089877
Received: 1 June 2012; in revised form: 6 July 2012 / Accepted: 26 July 2012 / Published: 8 August 2012
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Int. J. Mol. Sci. 2012, 13(8), 9649-9672; doi:10.3390/ijms13089649
Received: 18 June 2012; in revised form: 23 July 2012 / Accepted: 24 July 2012 / Published: 2 August 2012
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Int. J. Mol. Sci. 2012, 13(8), 9627-9641; doi:10.3390/ijms13089627
Received: 30 May 2012; in revised form: 15 July 2012 / Accepted: 25 July 2012 / Published: 2 August 2012
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Int. J. Mol. Sci. 2012, 13(8), 9545-9571; doi:10.3390/ijms13089545
Received: 8 June 2012; in revised form: 13 July 2012 / Accepted: 17 July 2012 / Published: 30 July 2012
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Int. J. Mol. Sci. 2012, 13(7), 9363-9379; doi:10.3390/ijms13079363
Received: 30 May 2012; in revised form: 18 July 2012 / Accepted: 19 July 2012 / Published: 24 July 2012
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Int. J. Mol. Sci. 2012, 13(7), 9069-9080; doi:10.3390/ijms13079069
Received: 24 May 2012; in revised form: 3 July 2012 / Accepted: 4 July 2012 / Published: 20 July 2012
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Int. J. Mol. Sci. 2012, 13(7), 8834-8852; doi:10.3390/ijms13078834
Received: 1 June 2012; in revised form: 30 June 2012 / Accepted: 4 July 2012 / Published: 16 July 2012
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Int. J. Mol. Sci. 2012, 13(7), 7886-7901; doi:10.3390/ijms13077886
Received: 1 June 2012; in revised form: 18 June 2012 / Accepted: 20 June 2012 / Published: 25 June 2012
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Int. J. Mol. Sci. 2012, 13(6), 6548-6560; doi:10.3390/ijms13066548
Received: 17 April 2012; in revised form: 21 May 2012 / Accepted: 22 May 2012 / Published: 29 May 2012
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Int. J. Mol. Sci. 2012, 13(5), 6246-6265; doi:10.3390/ijms13056246
Received: 13 March 2012; in revised form: 9 May 2012 / Accepted: 11 May 2012 / Published: 21 May 2012
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Last update: 24 April 2014

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