Special Issue "Applications of Circular Dichroism"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry, Theoretical and Computational Chemistry".
Deadline for manuscript submissions: closed (31 January 2012)
Prof. Dr. David Kliger
Department of Chemistry and Biochemistry; University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Chiroptical phenomena have been known for two centuries. However, new developments over the past 20 – 30 years have greatly expanded the capability and versatility of chiroptical spectroscopy, as evidenced by the articles in this special issue.
Biot first observed optical rotation, and he and Fresnel studied the phenomenon in the early 1800’s. In the mid 1800’s Pasteur related the phenomenon to molecular asymmetry. Since that time optical rotation (OR), and the related phenomenon of circular dichroism (CD), have been used in innumerable studies of molecular structures.
Early studies of chiroptical phenomena, of course, did not have the use of electronic devices that we now take for granted, so they involved measurements of optical rotation using null techniques detected visually. This situation changed as photoelectric light detectors were developed along with electronic devices to record light intensities in the twentieth century. With the advent of fast modulators of light polarization and phase sensitive measurement techniques, it became possible to measure differences in the absorption of left and right circularly polarized light with high sensitivity. CD spectroscopy then became a more common tool for molecular structure determinations since CD spectra can more easily be correlated with molecular structure than OR spectra and because instruments capable of producing sensitive measurements of visible and ultraviolet CD spectra, became commercially available.
The more recent developments of the past several decades have again expanded the capabilities of chiroptical spectroscopy by opening up access to spectral regions and higher order optical effects sensitive to additional features of molecular structure, by extending time resolution to the very fast time scales of fundamental molecular processes, and by advancing the theoretical understanding needed to interpret the structural implications of chiroptical spectra. Circularly polarized luminescence spectroscopy has increased the sensitivity of CD measurements of emitting chiral molecules. Structural determinations have been improved by making CD measurements farther into the UV region and even extending CD measurements into the X-ray and IR regions. IR measurements of CD monitor anisotropies of vibrational transitions and are thus particularly sensitive to local structural features. Similar capabilities have also been introduced with the development of Raman optical activity measurements. Highly sensitive measurements of local structural features around aromatic moieties have also been made possible with the development of magnetic circular dichroism. Techniques have also been developed to measure CD spectra with nanosecond or even picosecond or femtoseconds time resolution. These new developments, and improved theoretical analyses of CD spectra, have brought new capabilities to this old technique, thus made it useful for new applications. This issue explores a variety of such new applications of CD spectroscopy.
Prof. Dr. David Kliger
- chiroptical phenomena
- circular dichroism
- magnetic circular dichroism
- optical activity
- Raman optical activity
- vibrational circular dichroism
- structure determination
- time-resolved circular dichroism
Int. J. Mol. Sci. 2012, 13(3), 3394-3413; doi:10.3390/ijms13033394
Received: 21 January 2012; in revised form: 22 February 2012 / Accepted: 24 February 2012 / Published: 12 March 2012| Download PDF Full-text (728 KB) | View HTML Full-text | Download XML Full-text
Int. J. Mol. Sci. 2012, 13(2), 2459-2471; doi:10.3390/ijms13022459
Received: 6 January 2012; in revised form: 9 February 2012 / Accepted: 13 February 2012 / Published: 22 February 2012| Download PDF Full-text (376 KB) | View HTML Full-text | Download XML Full-text | Supplementary Files
Int. J. Mol. Sci. 2012, 13(2), 2239-2248; doi:10.3390/ijms13022239
Received: 5 January 2012; in revised form: 2 February 2012 / Accepted: 13 February 2012 / Published: 17 February 2012| Download PDF Full-text (215 KB) | View HTML Full-text | Download XML Full-text
Review: Probing Kinetic Mechanisms of Protein Function and Folding with Time-Resolved Natural and Magnetic Chiroptical Spectroscopies
Int. J. Mol. Sci. 2012, 13(1), 683-697; doi:10.3390/ijms13010683
Received: 23 December 2011; in revised form: 5 January 2012 / Accepted: 5 January 2012 / Published: 10 January 2012| Download PDF Full-text (223 KB) | View HTML Full-text | Download XML Full-text
Review: Chiral Vibrational Structures of Proteins at Interfaces Probed by Sum Frequency Generation Spectroscopy
Int. J. Mol. Sci. 2011, 12(12), 9404-9425; doi:10.3390/ijms12129404
Received: 8 November 2011; in revised form: 13 December 2011 / Accepted: 13 December 2011 / Published: 16 December 2011| Download PDF Full-text (963 KB) | View HTML Full-text | Download XML Full-text
Review: X-Ray Detected Magnetic Resonance: A Unique Probe of the Precession Dynamics of Orbital Magnetization Components
Int. J. Mol. Sci. 2011, 12(12), 8797-8835; doi:10.3390/ijms12128797
Received: 11 October 2011; in revised form: 12 November 2011 / Accepted: 15 November 2011 / Published: 2 December 2011| Download PDF Full-text (608 KB) | View HTML Full-text | Download XML Full-text
Article: 3,3′-Diethylthiatricarbocyanine Iodide: A Highly Sensitive Chiroptical Reporter of DNA Helicity and Sequence
Int. J. Mol. Sci. 2011, 12(11), 8052-8062; doi:10.3390/ijms12118052
Received: 21 October 2011; in revised form: 2 November 2011 / Accepted: 7 November 2011 / Published: 16 November 2011| Download PDF Full-text (1148 KB) | View HTML Full-text | Download XML Full-text | Supplementary Files
Article: Environmental Dependence of Artifact CD Peaks of Chiral Schiff Base 3d-4f Complexes in Soft Mater PMMA Matrix
Int. J. Mol. Sci. 2011, 12(10), 6966-6979; doi:10.3390/ijms12106966
Received: 13 September 2011; in revised form: 10 October 2011 / Accepted: 14 October 2011 / Published: 19 October 2011| Download PDF Full-text (721 KB) | View HTML Full-text | Download XML Full-text
Int. J. Mol. Sci. 2011, 12(9), 5797-5814; doi:10.3390/ijms12095797
Received: 18 July 2011; in revised form: 5 August 2011 / Accepted: 11 August 2011 / Published: 9 September 2011| Download PDF Full-text (483 KB) | View HTML Full-text | Download XML Full-text | Supplementary Files
Last update: 26 February 2014