Special Issue "Oxidative Stress in Cardiovascular Disease 2014"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology".

Deadline for manuscript submissions: 30 June 2015

Special Issue Editors

Guest Editor
Dr. Francis J. Miller Jr.
Departments of Internal Medicine and Anatomy and Cell Biology, University of Iowa, Veterans Affairs Medical Center, Iowa City, Iowa, USA
Website: http://www.int-med.uiowa.edu/divisions/cardiology/Directory/FrancisMiller.html
E-Mail: francis-miller@uiowa.edu
Interests: atherosclerosis; reactive oxygen species; oxidative stress; smooth muscle cells; NADPH oxidases; restenosis; redox signaling

Guest Editor
Dr. Gabor Csanyi
Vascular Medicine Institute, E1228-1B BST, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Website: http://www.vmi.pitt.edu/Csanyi.html
E-Mail: gac22@pitt.edu
Interests: oxidative stress, reactive oxygen species, NADPH oxidase, cardiovascular disease, vascular tone dysfunction, thrombospondins, nitric oxide, prostanoids, and EDHF

Guest Editor
Dr. Grant Drummond
Department of Pharmacology, Monash University, Victoria 3800, Australia
Website: http://www.med.monash.edu.au/pharmacology/staff/grant-drummond.html
E-Mail: grant.drummond@monash.edu

Special Issue Information

Dear Colleagues,

Cardiovascular disease is the leading cause of mortality and the most expensive health condition in the United States. Animal and human data implicate increased levels of reactive oxygen species (ROS) associated with oxidative stress in the pathogenesis of cardiovascular disease. Whereas ROS are essential for normal cellular processes, the molecular effects of increased ROS include the oxidation of DNA, RNA, lipids and proteins resulting in the dysregulation of ion channels, signaling pathways and transcription factors. However, we still do not have a complete understanding of the underlying mechanisms and consequences of increased ROS generation in cardiovascular tissue. Reducing oxidative stress represents a promising approach for prevention and treatment of cardiovascular disease. However, in numerous clinical trials, antioxidant supplementation failed to reduce cardiovascular morbidity or mortality. Therefore, alternative strategies are to achieve targeted delivery of antioxidants or to inhibit specific enzymatic sources of ROS, which include the mitochondria,  NADPH oxidases, xanthine oxidase, lipooxygenase, cyclooxygenase, and nitric oxide synthase. This special issue will focus on the causes and consequence of oxidative stress in cardiovascular disease and explore emerging treatment strategies.

Prof. Dr. Francis Miller, Jr.
Dr. Gabor Csanyi
Dr. Grant Drummond
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).


Keywords

  • oxidative stress, reactive oxygen species
  • heart disease, myocardial infarction, ischemia/reperfusion, preconditioning
  • vascular disease, atherosclerosis, hypertension, restenosis, stroke, thrombosis
  • biomarkers of oxidative stress
  • redox-mediated signaling
  • transcription factors, antioxidant response elements
  • antioxidant therapy

Related Special Issue

Published Papers (13 papers)

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Displaying article 1-13
p. 23792-23835
by , ,  and
Int. J. Mol. Sci. 2014, 15(12), 23792-23835; doi:10.3390/ijms151223792 (registering DOI)
Received: 30 October 2014; in revised form: 5 December 2014 / Accepted: 10 December 2014 / Published: 19 December 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 23059-23073
by , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(12), 23059-23073; doi:10.3390/ijms151223059
Received: 27 October 2014; in revised form: 28 November 2014 / Accepted: 4 December 2014 / Published: 11 December 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 22203-22213
by , , , ,  and
Int. J. Mol. Sci. 2014, 15(12), 22203-22213; doi:10.3390/ijms151222203
Received: 27 October 2014; in revised form: 17 November 2014 / Accepted: 26 November 2014 / Published: 2 December 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 21754-21776
by , ,  and
Int. J. Mol. Sci. 2014, 15(12), 21754-21776; doi:10.3390/ijms151221754
Received: 20 October 2014; in revised form: 17 November 2014 / Accepted: 19 November 2014 / Published: 26 November 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 20997-21010
by , ,  and
Int. J. Mol. Sci. 2014, 15(11), 20997-21010; doi:10.3390/ijms151120997
Received: 23 October 2014; Accepted: 10 November 2014 / Published: 14 November 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 20079-20100
by , , , ,  and
Int. J. Mol. Sci. 2014, 15(11), 20079-20100; doi:10.3390/ijms151120079
Received: 23 August 2014; in revised form: 17 October 2014 / Accepted: 21 October 2014 / Published: 4 November 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 19417-19443
by , ,  and
Int. J. Mol. Sci. 2014, 15(11), 19417-19443; doi:10.3390/ijms151119417
Received: 5 August 2014; in revised form: 30 September 2014 / Accepted: 8 October 2014 / Published: 27 October 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 19203-19225
by  and
Int. J. Mol. Sci. 2014, 15(10), 19203-19225; doi:10.3390/ijms151019203
Received: 27 August 2014; in revised form: 29 September 2014 / Accepted: 2 October 2014 / Published: 22 October 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 18362-18380
by , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(10), 18362-18380; doi:10.3390/ijms151018362
Received: 29 May 2014; in revised form: 27 September 2014 / Accepted: 29 September 2014 / Published: 13 October 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
p. 18381-18406
by
Int. J. Mol. Sci. 2014, 15(10), 18381-18406; doi:10.3390/ijms151018381
Received: 26 August 2014; in revised form: 16 September 2014 / Accepted: 28 September 2014 / Published: 13 October 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
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p. 11773-11782
by  and
Int. J. Mol. Sci. 2014, 15(7), 11773-11782; doi:10.3390/ijms150711773
Received: 27 May 2014; in revised form: 24 June 2014 / Accepted: 27 June 2014 / Published: 2 July 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
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p. 11324-11349
by III and Jr.
Int. J. Mol. Sci. 2014, 15(7), 11324-11349; doi:10.3390/ijms150711324
Received: 9 May 2014; in revised form: 23 May 2014 / Accepted: 6 June 2014 / Published: 25 June 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
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p. 9036-9050
by , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(5), 9036-9050; doi:10.3390/ijms15059036
Received: 17 April 2014; in revised form: 12 May 2014 / Accepted: 14 May 2014 / Published: 21 May 2014
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(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2014)
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Last update: 21 November 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert