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Special Issue "Selected Papers from 3-ISPMF, 3rd International Symposium on Phytochemicals in Medicine and Food (Kunming, 2018)"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 15 April 2018

Special Issue Editors

Guest Editor
Prof. Dr. Jianbo Xiao

Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
E-Mail
Interests: phytochemicals; polyphenols; diabetes; function food; natural products; glycosylation; biological activity; flavonoids; stilbenoids; pharmacokinetics; nutrition and metabolism; polyphenol-protein interaction
Guest Editor
Prof. Dr. Miron Anca

Dept. Pharmacognosy-Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa",Universitatii Street, No 16, 700115, Iasi, Romania
E-Mail
Interests: phytochemicals; natural products; plant biodiversity; medicinal plants; food plants; bioactivity; polyphenols; glucosinolates; biocides
Guest Editor
Prof. Dr. Yongliang Zhuang

Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, Yunnan, China
E-Mail
Interests: polysaccharides; peptide; natural products; function foods; biochemistry; nutrition; antioxidant agents and mechanisms; structure-activity relationships

Special Issue Information

Dear Colleagues,

This Special Issue is related to 3rd International Symposium on Phytochemicals in Medicine and Food (3-ISPMF), which will be held at the Kunming University of Science and Technology, 26–29 August, 2018. 3-ISPMF is sponsored by the Phytochemical Society of Europe (PSE), International Society for Chinese Medicine (ISCM), and the Phytochemical Society of Europe (PSA).

This Special Issue seeks updated and new knowledge on the phytochemicals in medicine and food. Evidence from epidemiological investigations shows that natural phytochemicals have received increased attention due to their considerable benefits in preventing and managing modern diseases, such as cancers, diabetes, and cardiovascular diseases. This Special Issue will shape the future research direction for this important phytomedicine source. Our purpose is to feature high quality advanced research and knowledge, contributed by various research groups around the world, working on phytochemicals. We invite researchers to contribute reviews and reports of their recent work on the chemistry, biology and biotechnology of phytochemicals.

The Special Issue will focus on the phytochemicals in medicine and food, and will include the following aspects:

  • Natural products for the prevention and therapy of modern diseases.
  • Mechanism of phytochemicals for therapy and chemoprevention of modern diseases.
  • Importance of natural phytochemicals in medicine and food
  • QSAR and modeling for natural drugs design.
  • Natural antioxidants and human health.
  • New strategy of using natural products for managing diseases
  • Pharmacokinetics and biotransformation of phytochemicals

Prof. Dr. Jianbo Xiao
Prof. Dr. Miron Anca
Prof. Dr. Yongliang Zhuang

Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Phytochemicals
  • Medicinal plants
  • Natural products
  • Food chemistry
  • Phytomedicine
  • Metabolism
  • Prevention
  • Chemoprevention
  • Function food
  • Pharmacokinetics
  • Biotransformation
  • Structure-activity relationships

Published Papers (7 papers)

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Research

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Open AccessArticle Identification and Antithrombotic Activity of Peptides from Blue Mussel (Mytilus edulis) Protein
Int. J. Mol. Sci. 2018, 19(1), 138; doi:10.3390/ijms19010138
Received: 23 November 2017 / Revised: 14 December 2017 / Accepted: 20 December 2017 / Published: 4 January 2018
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Abstract
The blue mussel (Mytilus edulis) reportedly contains many bioactive components of nutritional value. Water-, salt- and acid-soluble M. edulis protein fractions were obtained and the proteins were trypsinized. The resultant peptides were analyzed by ultra-performance liquid chromatography quadrupole time of flight
[...] Read more.
The blue mussel (Mytilus edulis) reportedly contains many bioactive components of nutritional value. Water-, salt- and acid-soluble M. edulis protein fractions were obtained and the proteins were trypsinized. The resultant peptides were analyzed by ultra-performance liquid chromatography quadrupole time of flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS). 387 unique peptides were identified that matched 81 precursor proteins. Molecular mass distributions of the proteins and peptides were analyzed by sodium dodecyl sulfate-polyacryl amide gel electrophoresis (SDS-PAGE). The differences between the three protein samples were studied by Venn diagram of peptide and protein compositions. Toxicity, allergic and antithrombotic activity of peptides was predicted using database website and molecular docking respectively. The antithrombotic activity of enzymatic hydrolysate from water-, salt- and acid-soluble M. edulis protein were 40.17%, 85.74%, 82.00% at 5 mg/mL, respectively. Active mechanism of antithrombotic peptide (ELEDSLDSER) was also research about amino acid binding sites and interaction, simultaneously. Full article
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Open AccessArticle Genome-Wide Analysis of Long Non-Coding RNAs in Potato and Their Potential Role in Tuber Sprouting Process
Int. J. Mol. Sci. 2018, 19(1), 101; doi:10.3390/ijms19010101
Received: 23 November 2017 / Revised: 20 December 2017 / Accepted: 28 December 2017 / Published: 29 December 2017
PDF Full-text (2685 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Sprouting is a key factor affecting the quality of potato tubers. The present study aimed to compare the differential expression of long non-coding RNAs (lncRNAs) in the apical meristem during the dormancy release and sprouting stages by using lncRNA sequencing. Microscopic observations and
[...] Read more.
Sprouting is a key factor affecting the quality of potato tubers. The present study aimed to compare the differential expression of long non-coding RNAs (lncRNAs) in the apical meristem during the dormancy release and sprouting stages by using lncRNA sequencing. Microscopic observations and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed the changes in the morphology and expression of lncRNAs in potato tubers during sprouting. Meristematic cells of potato tuber apical buds divided continuously and exhibited vegetative cone bulging and vascularisation. In all, 3175 lncRNAs were identified from the apical buds of potato tubers, among which 383 lncRNAs were up-regulated and 340 were down-regulated during sprouting. The GO enrichment analysis revealed that sprouting mainly influenced the expression of lncRNAs related to the cellular components of potato apical buds (e.g., cytoplasm and organelles) and cellular metabolic processes. The KEGG enrichment analysis also showed significant enrichment of specific metabolic pathways. In addition, 386 differentially expressed lncRNAs during sprouting were identified as putative targets of 235 potato miRNAs. Quantitative real-time polymerase chain reaction results agreed with the sequencing data. Our study provides the first systematic study of numerous lncRNAs involved in the potato tuber sprouting process and lays the foundation for further studies to elucidate their precise functions. Full article
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Open AccessArticle Mussel-Inspired Fabrication of Konjac Glucomannan/Poly (Lactic Acid) Cryogels with Enhanced Thermal and Mechanical Properties
Int. J. Mol. Sci. 2017, 18(12), 2714; doi:10.3390/ijms18122714
Received: 11 October 2017 / Revised: 30 November 2017 / Accepted: 12 December 2017 / Published: 16 December 2017
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Abstract
Three-dimensional nanofibers cryogels (NFCs) with both thermally-tolerant and mechanically-robust properties have potential for wide application in biomedical or food areas; however, creating such NFCs has proven to be extremely challenging. In this study, konjac glucomannan (KGM)/poly (lactic acid) (PLA)-based novel NFCs were prepared
[...] Read more.
Three-dimensional nanofibers cryogels (NFCs) with both thermally-tolerant and mechanically-robust properties have potential for wide application in biomedical or food areas; however, creating such NFCs has proven to be extremely challenging. In this study, konjac glucomannan (KGM)/poly (lactic acid) (PLA)-based novel NFCs were prepared by the incorporation of the mussel-inspired protein polydopamine (PDA) via a facile and environmentally-friendly electrospinning and freeze-shaping technique. The obtained KGM/PLA/PDA (KPP) NFCs were characterized by field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and compressive and tensile test. The results showed that the hierarchical cellular structure and physicochemical properties of KPP NFCs were dependent on the incorporation of PDA content. Moreover, the strong intermolecular hydrogen bond interactions among KGM, PLA and PDA also gave KPP NFCs high thermostability and mechanically-robust properties. Thus, this study developed a simple approach to fabricate multifunctional NFCs with significant potential for biomedical or food application. Full article
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Open AccessArticle The Candida albicans Inhibitory Activity of the Extract from Papaya (Carica papaya L.) Seed Relates to Mitochondria Dysfunction
Int. J. Mol. Sci. 2017, 18(9), 1858; doi:10.3390/ijms18091858
Received: 26 July 2017 / Revised: 16 August 2017 / Accepted: 18 August 2017 / Published: 25 August 2017
Cited by 1 | PDF Full-text (1398 KB) | HTML Full-text | XML Full-text
Abstract
The inhibitory activity of the papaya seed extract (PSE) on Candida albicans (C. albicans) was determined by turbidimetry method. The inhibitory mechanisms were also evaluated from the prospective of reactive oxygen species (ROS) generation, mitochondrial membrane potential (MMP) decrease, and the
[...] Read more.
The inhibitory activity of the papaya seed extract (PSE) on Candida albicans (C. albicans) was determined by turbidimetry method. The inhibitory mechanisms were also evaluated from the prospective of reactive oxygen species (ROS) generation, mitochondrial membrane potential (MMP) decrease, and the activities of four complex enzymes in mitochondria respiratory chain. Results obtained from this study indicated that the PSE exhibited an effective inhibitory activity on C. albicans and induced significant accumulation of ROS and collapse of MMP. The Complex I and Complex III exhibited continues significant decrease in mitochondrial enzyme activity assays, but the Complex II and Complex IV activities were not positively correlated. Furthermore, the GC-MS analysis demonstrated that the PSE represents a rich and high-purity source of benzyl isothiocyanate (BITC), which indicated the BITC may be responsible for the mitochondrial dysfunction. Full article
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Open AccessArticle GC-MS Fingerprinting Combined with Chemometric Methods Reveals Key Bioactive Components in Acori Tatarinowii Rhizoma
Int. J. Mol. Sci. 2017, 18(7), 1342; doi:10.3390/ijms18071342
Received: 16 May 2017 / Revised: 12 June 2017 / Accepted: 20 June 2017 / Published: 3 July 2017
PDF Full-text (1785 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
This present study aims to identify the key bioactive components in acorus tatarinowii rhizoma (ATR), a traditional Chinese medicine (TCM) with various bioactivities. Partial least squares regression (PLSR) was employed to describe the relationship between the radical scavenging activity and the volatile components.
[...] Read more.
This present study aims to identify the key bioactive components in acorus tatarinowii rhizoma (ATR), a traditional Chinese medicine (TCM) with various bioactivities. Partial least squares regression (PLSR) was employed to describe the relationship between the radical scavenging activity and the volatile components. The PLSR model was improved by outlier elimination and variable selection and was evaluated by 10-fold cross-validation and external validation in this study. Based on the PLSR model, eleven chemical components were identified as the key bioactive components by variable importance in projection. The final PLS regression model with these components has good predictive ability. The Q2 was 0.8284, and the root mean square error for prediction was 2.9641. The results indicated that the eleven components could be a pattern to predict the radical scavenging activity of ATR. In addition, we did not find any specific relationship between the radical scavenging ability and the habitat of the ATRs. This study proposed an efficient strategy to predict bioactive components using the combination of quantitative chromatography fingerprints and PLS regression, and has potential perspective for screening bioactive components in complex analytical systems, such as TCM. Full article
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Review

Jump to: Research

Open AccessReview Recent Advances in Momordica charantia: Functional Components and Biological Activities
Int. J. Mol. Sci. 2017, 18(12), 2555; doi:10.3390/ijms18122555
Received: 20 October 2017 / Revised: 20 November 2017 / Accepted: 22 November 2017 / Published: 28 November 2017
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Abstract
Momordica charantia L. (M. charantia), a member of the Cucurbitaceae family, is widely distributed in tropical and subtropical regions of the world. It has been used in folk medicine for the treatment of diabetes mellitus, and its fruit has been used
[...] Read more.
Momordica charantia L. (M. charantia), a member of the Cucurbitaceae family, is widely distributed in tropical and subtropical regions of the world. It has been used in folk medicine for the treatment of diabetes mellitus, and its fruit has been used as a vegetable for thousands of years. Phytochemicals including proteins, polysaccharides, flavonoids, triterpenes, saponins, ascorbic acid and steroids have been found in this plant. Various biological activities of M. charantia have been reported, such as antihyperglycemic, antibacterial, antiviral, antitumor, immunomodulation, antioxidant, antidiabetic, anthelmintic, antimutagenic, antiulcer, antilipolytic, antifertility, hepatoprotective, anticancer and anti-inflammatory activities. However, both in vitro and in vivo studies have also demonstrated that M. charantia may also exert toxic or adverse effects under different conditions. This review addresses the chemical constituents of M. charantia and discusses their pharmacological activities as well as their adverse effects, aimed at providing a comprehensive overview of the phytochemistry and biological activities of M. charantia. Full article
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Open AccessReview A Review on Konjac Glucomannan Gels: Microstructure and Application
Int. J. Mol. Sci. 2017, 18(11), 2250; doi:10.3390/ijms18112250
Received: 26 August 2017 / Revised: 2 October 2017 / Accepted: 12 October 2017 / Published: 27 October 2017
PDF Full-text (18796 KB) | HTML Full-text | XML Full-text
Abstract
Konjac glucomannan (KGM) has attracted extensive attention because of its biodegradable, non-toxic, harmless, and biocompatible features. Its gelation performance is one of its most significant characteristics and enables wide applications of KGM gels in food, chemical, pharmaceutical, materials, and other fields. Herein, different
[...] Read more.
Konjac glucomannan (KGM) has attracted extensive attention because of its biodegradable, non-toxic, harmless, and biocompatible features. Its gelation performance is one of its most significant characteristics and enables wide applications of KGM gels in food, chemical, pharmaceutical, materials, and other fields. Herein, different preparation methods of KGM gels and their microstructures were reviewed. In addition, KGM applications have been theoretically modeled for future uses. Full article
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