Special Issue "Antimicrobial Electrospun Fibers"

A special issue of Fibers (ISSN 2079-6439).

Deadline for manuscript submissions: 15 December 2018

Special Issue Editor

Guest Editor
Prof. Dr. Jordi Puiggalí

Chemical Engineering Department. Universitat Politècnica de Catalunya, c/Eduard Maristany, 08019 Barcelona, Spain
Website | E-Mail
Interests: structure of synthetic polymers; development of biodegradable polymers; study of nanocomposites; polymer physics; polymer crystallization

Special Issue Information

Dear Colleagues,

Development of materials with a bactericide activity is essential to avoid health and environmental problems, being probably the biomedical and food-packaging sectors those most interested in this research. Different solutions have been proposed to suppress biofilm formation and get appropriate materials for both specialty and commodity applications. A usual practice consists in the incorporation of industrial and clinical bactericide agents (e.g., silver, copper, quaternary ammonium derivatives and antibiotics), as well as the use of antimicrobial polymers. The incorporation of bacteriophages appears also a promising alternative to the typical use of antibiotics.

Nowadays, electrospinning is an economic and versatile process that allows getting porous scaffolds constituted by micro/nanofibers of antimicrobial polymers and synthetic polymers that incorporate the above indicated bactericidal compounds. In fact, single electrospinning, co-electrospinning, coaxial electrospinning and miniemulsion electrospinning are available processes that can be chosen according to hydrophilicity/hydrophobicity of loaded compounds and the control of the release.

This Special Issue of Fibers aims to discuss, collect and offer recent highlights and advances on the production of antimicrobial nanofibers. To this end, the progress on the development of bactericide systems, the preparation methods and the evaluation of bactericide effectiveness are some of the specific topics that should be considered. 

Prof. Dr. Jordi Puiggalí
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fibers is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Electrospinning
  • Drug encapsulation
  • Chitosan
  • Hydantoin compounds
  • Antibiotics
  • Bactericides
  • Quaternary ammonium compounds
  • Bacteriophages
  • Metal particles
  • Halamine compounds

Published Papers (1 paper)

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Research

Open AccessArticle Antimicrobial Activity of Poly(ester urea) Electrospun Fibers Loaded with Bacteriophages
Fibers 2018, 6(2), 33; https://doi.org/10.3390/fib6020033
Received: 2 April 2018 / Revised: 7 May 2018 / Accepted: 9 May 2018 / Published: 23 May 2018
PDF Full-text (7413 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The capacity to load bacteriophages into electrospun nanofibers of two representative biocompatible polymers has been evaluated, paying special attention to the possibility of preserving their antibacterial activity. Specifically, the work involves the following steps: (a) Evaluation of the effect of the applied electrical
[...] Read more.
The capacity to load bacteriophages into electrospun nanofibers of two representative biocompatible polymers has been evaluated, paying special attention to the possibility of preserving their antibacterial activity. Specifically, the work involves the following steps: (a) Evaluation of the effect of the applied electrical field on the phage activity; (b) evaluation of the activity when a lyophilization process could be avoided by using water soluble polymers (e.g., poly(ethylene glycol); (c) evaluation of the activity when dissolution of the polymer requires an organic solvent and lyophilization is theoretically necessary. In this case, a poly(ester urea) (PEU) derived from the natural L-leucine amino acid has been considered. Adsorption of commercial bacteriophage preparations into calcium carbonate particles was demonstrated to be a promising methodology to avoid lyophilization and keep the initial bactericide activity at a maximum. Phagestaph and Fersis bacteriophage commercial preparations have been selected for this study due to their specific activity against Staphylococci (e.g., S. aureus) and Streptococci (e.g., S. pyogenes) bacteria. Adhesion and proliferation assays using epithelial cells demonstrated the biocompatibility of both unloaded and bacteriophage-loaded PEU scaffolds, although some slight differences were observed depending on the type of bacteriophage and the selected preparation methodology. Full article
(This article belongs to the Special Issue Antimicrobial Electrospun Fibers)
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