Special Issue "Photoactive Transition Metal Carbonyls and Nitrosyls: Structures, Properties and Sustainable Delivery of the Gasotransmitters Towards Biological Targets"
A special issue of Crystals (ISSN 2073-4352).
Deadline for manuscript submissions: 31 May 2018
It has been well-established, from research work of the past few decades, that the three small “toxic” gaseous molecules, namely nitric oxide (NO), carbon-monoxide (CO) and hydrogen sulphide (H2S), act as very important signalling molecules in mammalian pathophysiology. Interestingly, all these molecules are produced endogenously and appropriate modulation of these molecules on specific sites lead to a variety of salutary effects. Among the three gasotransmitters, the physiological effects of CO and NO have been relatively studied in-depth compared to H2S. One of the major limitations toward the clinical application of CO and NO is a lack of controlled delivery and site specificity. As a consequence, the quest of designing appropriate CO and NO donors that can deliver low doses of these gasotransmitters under controlled conditions has gained significant impetus. Metal carbonyl and metal nitrosyl pro-drug complexes are attractive choices as CO and NO donors, respectively, due to their well-studied photophysical and photochemical properties. Among others, photoactive metal carbonyl and metal nitrosyl complexes offer a facile way to trigger the release of CO and NO with superior temporal and spatial control, and thereby enhancing the concentration of drugs (CO and NO) to the site of interest and to minimize side effects due to global exposure.
The Special issue, “Photoactive Transition Metal Carbonyls and Nitrosyls: Structures, Properties and Sustainable Delivery of the Gasotransmitters Towards Biological Targets” is intended to provide a platform to cover the area of novel photoactive metal carbonyl and nitrosyl complexes and their possible applications towards biological targets. New complexes with structural descriptions, photo activity and biological applications are invited.
Prof. Indranil Chakraborty
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Metal carbonyls
- Metal nitrosyls