Special Issue "Photoactive Transition Metal Carbonyls and Nitrosyls: Structures, Properties and Sustainable Delivery of the Gasotransmitters Towards Biological Targets"
A special issue of Crystals (ISSN 2073-4352).
Deadline for manuscript submissions: 31 May 2018
It has been well-established, from research work of the past few decades, that the three small “toxic” gaseous molecules, namely nitric oxide (NO), carbon-monoxide (CO) and hydrogen sulphide (H2S), act as very important signalling molecules in mammalian pathophysiology. Interestingly, all these molecules are produced endogenously and appropriate modulation of these molecules on specific sites lead to a variety of salutary effects. Among the three gasotransmitters, the physiological effects of CO and NO have been relatively studied in-depth compared to H2S. One of the major limitations toward the clinical application of CO and NO is a lack of controlled delivery and site specificity. As a consequence, the quest of designing appropriate CO and NO donors that can deliver low doses of these gasotransmitters under controlled conditions has gained significant impetus. Metal carbonyl and metal nitrosyl pro-drug complexes are attractive choices as CO and NO donors, respectively, due to their well-studied photophysical and photochemical properties. Among others, photoactive metal carbonyl and metal nitrosyl complexes offer a facile way to trigger the release of CO and NO with superior temporal and spatial control, and thereby enhancing the concentration of drugs (CO and NO) to the site of interest and to minimize side effects due to global exposure.
The Special issue, “Photoactive Transition Metal Carbonyls and Nitrosyls: Structures, Properties and Sustainable Delivery of the Gasotransmitters Towards Biological Targets” is intended to provide a platform to cover the area of novel photoactive metal carbonyl and nitrosyl complexes and their possible applications towards biological targets. New complexes with structural descriptions, photo activity and biological applications are invited.
Prof. Indranil Chakraborty
Manuscript Submission Information
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- Metal carbonyls
- Metal nitrosyls