Special Issue "Radiation Effects in Bio-Molecular and Organic Crystals"

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Biomolecular Crystals".

Deadline for manuscript submissions: 1 September 2018

Special Issue Editor

Guest Editor
Dr. Vivian Stojanoff

Brookhaven National Laboratory, National Synchrotron Light Source -II, USA
Website | E-Mail
Interests: high energy; radiation effects; crystallogenesis; imaging

Special Issue Information

Dear Colleagues,

Advances in X-ray sources that produce photon flux densities that can be focused in to micro- or even nano- sized beams and detection systems allow for an unprecedented amount of diffraction data in very short time. The promise of atomic resolution however is limited by the high dose deposited, causing severe damage to samples.  Leading to an overall sample degradation, radiation damage is known to affect specific sites within biological molecules; disulfide bond breakage and decarboxylation are examples of site-specific damage by radiation. In spite of several reports and systematic studies a conclusive model that describes the mechanism has remained elusive. This is the reason for this Special Issue on “Radiation Effects in Bio-Molecular and Organic Crystals” to be published in Crystals (ISSN 2073-4352, http://www.mdpi.com/journal/crystals). We encourage all specialists and experts on this topic to submit original contributions to this journal, and to the thematic issue for consideration and publication.

Potential topics include, but are not limited to:

  • simulations of radiation damage
  • femtosecond crystallography
  • dose dependence of radiation damage
  • temperature dependence of radiation damage
  • energy dependent radiation damage effects
  • radiation damage in cryo-electron microscopy
  • radiation damage dependence on molecular size and nature
  • radiation effects in microcrystals
  • radiation effects in macrocrystals
  • radiation damage effects and molecular dynamics.

The first round submission deadline: 20 February 2018

Dr. Vivian Stojanoff
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessCommunication Electronic Excitations and Radiation Damage in Macromolecular Crystallography
Crystals 2018, 8(7), 273; https://doi.org/10.3390/cryst8070273
Received: 11 May 2018 / Revised: 21 June 2018 / Accepted: 26 June 2018 / Published: 29 June 2018
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Abstract
Macromolecular crystallography at cryogenic temperatures has so far provided the majority of the experimental evidence that underpins the determination of the atomic structures of proteins and other biomolecular assemblies by means of single crystal X-ray diffraction experiments. One of the core limitations of
[...] Read more.
Macromolecular crystallography at cryogenic temperatures has so far provided the majority of the experimental evidence that underpins the determination of the atomic structures of proteins and other biomolecular assemblies by means of single crystal X-ray diffraction experiments. One of the core limitations of the current methods is that crystal samples degrade as they are subject to X-rays, and two broad groups of effects are observed: global and specific damage. While the currently successful approach is to operate outside the range where global damage is observed, specific damage is not well understood and may lead to poor interpretation of the chemistry and biology of the system under study. In this work, we present a phenomenological model in which specific damage is understood as the result of a single process, the steady excitation of crystal electrons caused by X-ray absorption, which acts as a trigger for the bulk effects that manifest themselves in the form of global damage and obscure the interpretation of chemical information from XFEL and synchrotron structural research. Full article
(This article belongs to the Special Issue Radiation Effects in Bio-Molecular and Organic Crystals)
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