Special Issue "Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development"

A special issue of Catalysts (ISSN 2073-4344).

Deadline for manuscript submissions: 28 February 2019

Special Issue Editor

Guest Editor
Prof. Andres R Alcantara

Department of Chemistry in Pharmaceutical Sciences, Pharmacy Faculty, Complutense University,Plaza de Ramon y Cajal, S/N University City, Madrid, Spain
Website | E-Mail
Interests: enzymatic synthesis of drugs and bioactive compounds; sustainable processes; biocatalysts upgrading; pharmaceutical industry

Special Issue Information

Dear Colleagues,

In the last years, the advances in bioinformatics, enzyme evolution or process intensification have enlarged the effectiveness of biotransformations, accelerating the rate at which new enzymes are becoming available, even for promiscuous activities not previously known. Thus, now it is possible to join the exquisite enzymatic precision and inherent sustainability associated to the employ of biocatalysts with the possibility of generating new and more robust biocatalysts, expanding the biocatalytic toolbox, moving inside a time scale more compatible with the demands of pharmaceutical industry. For these reasons, it seems clear that we are entering in a new scenario, in which biocatalysis will play an even more significant role in such a competitive and demanding industry.

This Special Issue aims to gather contributions from research groups, rather original research or up-to-date revisions, to illustrate recent advances in this fascinating area. This includes, but is not restricted to, the discovery of new enzymatic activities, the chemical or genetic modification of known biocatalysts for further application in the development of new drugs, and the implementation of biocatalyzed protocols to increase the sustainability in the synthesis of drugs and bioactive molecules.

Prof. Andres R Alcantara
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biocatalysis
  • Biotransformations
  • Drug synthesis
  • Sustainable Chemistry
  • Biocatalyst engineering

Published Papers (1 paper)

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Research

Open AccessArticle Laccase Activity as an Essential Factor in the Oligomerization of Rutin
Catalysts 2018, 8(8), 321; https://doi.org/10.3390/catal8080321
Received: 9 July 2018 / Revised: 24 July 2018 / Accepted: 3 August 2018 / Published: 6 August 2018
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Abstract
The enzyme-mediated polymerization of bioactive phenolic compounds, such as the flavonoid rutin, has gained interest due to the enhanced physico-chemical and biological properties of the products, which increases their potential application as a nutraceutical. In this work, the influence of enzyme activity on
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The enzyme-mediated polymerization of bioactive phenolic compounds, such as the flavonoid rutin, has gained interest due to the enhanced physico-chemical and biological properties of the products, which increases their potential application as a nutraceutical. In this work, the influence of enzyme activity on rutin oligomerization was evaluated in reactions with low (1000 U/L) and high (10,000 U/L) initial laccase activities. For both reactions, high molecular weight oligomer fractions showed better properties compared to lower weight oligomers. Products of the reaction with low laccase activity exhibited thermal stability and antioxidant potential similar to control reaction, but led to higher inhibitory activity of xanthine oxidase and apparent aqueous solubility. Oligomers obtained in the reaction with high laccase activity showed better apparent aqueous solubility but decreased biological activities and stability. Their low antioxidant activity was correlated with a decreased phenolic content, which could be attributed to the formation of several bonds between rutin molecules. Full article
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