Special Issue "Autophagy and Cancer"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (31 January 2013)

Special Issue Editor

Guest Editor
Dr. Guillermo Velasco (Website)

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C/José Antonio Nováis nº 2, 28040 Madrid, Spain
Phone: +34 913944668
Fax: +34 913944672
Interests: autophagy; ER stress; gliomas; cannabinoid antitumoral action; ceramide signaling

Special Issue Information

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs).

Keywords

  • autophagy
  • mechanisms of autophagy-mediated cell death
  • role of autophagy in cancer generation and progression
  • regulation of autophagy by proteins interacting with the mTORC1 complex
  • role of sphingolipids on the regulation of autophagy

Published Papers (1 paper)

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Review

Open AccessReview Nanomaterials and Autophagy: New Insights in Cancer Treatment
Cancers 2013, 5(1), 296-319; doi:10.3390/cancers5010296
Received: 1 February 2013 / Revised: 5 March 2013 / Accepted: 19 March 2013 / Published: 21 March 2013
Cited by 8 | PDF Full-text (1166 KB) | HTML Full-text | XML Full-text
Abstract
Autophagy represents a cell’s response to stress. It is an evolutionarily conserved process with diversified roles. Indeed, it controls intracellular homeostasis by degradation and/or recycling intracellular metabolic material, supplies energy, provides nutrients, eliminates cytotoxic materials and damaged proteins and organelles. Moreover, autophagy [...] Read more.
Autophagy represents a cell’s response to stress. It is an evolutionarily conserved process with diversified roles. Indeed, it controls intracellular homeostasis by degradation and/or recycling intracellular metabolic material, supplies energy, provides nutrients, eliminates cytotoxic materials and damaged proteins and organelles. Moreover, autophagy is involved in several diseases. Recent evidences support a relationship between several classes of nanomaterials and autophagy perturbation, both induction and blockade, in many biological models. In fact, the autophagic mechanism represents a common cellular response to nanomaterials. On the other hand, the dynamic nature of autophagy in cancer biology is an intriguing approach for cancer therapeutics, since during tumour development and therapy, autophagy has been reported to trigger both an early cell survival and a late cell death. The use of nanomaterials in cancer treatment to deliver chemotherapeutic drugs and target tumours is well known. Recently, autophagy modulation mediated by nanomaterials has become an appealing notion in nanomedicine therapeutics, since it can be exploited as adjuvant in chemotherapy or in the development of cancer vaccines or as a potential anti-cancer agent. Herein, we summarize the effects of nanomaterials on autophagic processes in cancer, also considering the therapeutic outcome of synergism between nanomaterials and autophagy to improve existing cancer therapies. Full article
(This article belongs to the Special Issue Autophagy and Cancer)

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