Special Issue "Tumor Stroma"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (29 February 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Kristian Pietras
Karolinska Institute, Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Scheeles Väg 2, House A4, level 4, SE-171 77, Stockholm, Sweden
Website: http://ki.se/ki/jsp/polopoly.jsp?d=30531&l=en
E-Mail: kristian.pietras@ki.se
Phone: +46 8524 87891
Interests: molecular studies of the endothelial cell-pericyte interplay; carcinoma-associated fibroblasts: recruitment into tumors, phenotype and therapeutic opportunities; TGF-beta signaling in the tumor microenvironment

Special Issue Information

Dear Colleagues,

The process of tumorigenic conversion of normal cells by genetic events is paralleled by co-evolution of an activated stromal compartment. It is increasingly evident that the microenvironment in which a neoplastic lesion persists holds critical influence over cancer initiation, maintenance, growth and progression into a metastatic and lethal disease. The tumor stroma is populated by endothelial cells and pericytes in the angiogenic vasculature, various types of inflammatory cells of the innate and adaptive immune system, as well as by fibroblasts and a rich connective tissue. Collectively, the stromal components sustain tumor proliferation, survival, stem cell maintenance, angiogenesis, invasiveness and distant spread. As such, the tumor microenvironment is an attractive target for novel anti-cancer therapies. The special issue of Cancers on “Tumor Stroma” will include original research articles and review articles on the influence of the microenvironment on all aspects of tumor biology.

We are looking forward to your contributions.

Prof. Dr. Kristian Pietras
Guest Editor

Keywords

  • tumor stroma
  • microenvironment
  • angiogenesis
  • cancer-associated fibroblast
  • inflammation
  • cancer stem cell niche
  • extra-cellular matrix
  • metastasis
  • targeted therapy
  • paracrine growth factor signaling

Published Papers (12 papers)

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Displaying article 1-12
p. 205-217
by , , ,  and
Cancers 2013, 5(1), 205-217; doi:10.3390/cancers5010205
Received: 26 January 2013; in revised form: 26 January 2013 / Accepted: 6 February 2013 / Published: 18 February 2013
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(This article belongs to the Special Issue Tumor Stroma)
abstract graphic
p. 873-903
by , , , ,  and
Cancers 2012, 4(3), 873-903; doi:10.3390/cancers4030873
Received: 25 June 2012; in revised form: 28 August 2012 / Accepted: 31 August 2012 / Published: 6 September 2012
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(This article belongs to the Special Issue Tumor Stroma)
p. 821-845
by , , , , , ,  and
Cancers 2012, 4(3), 821-845; doi:10.3390/cancers4030821
Received: 16 July 2012; in revised form: 17 August 2012 / Accepted: 21 August 2012 / Published: 29 August 2012
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(This article belongs to the Special Issue Tumor Stroma)
abstract graphic
p. 701-724
by
Cancers 2012, 4(3), 701-724; doi:10.3390/cancers4030701
Received: 17 May 2012; in revised form: 29 June 2012 / Accepted: 12 July 2012 / Published: 18 July 2012
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(This article belongs to the Special Issue Tumor Stroma)
p. 618-657
by  and
Cancers 2012, 4(3), 618-657; doi:10.3390/cancers4030618
Received: 2 May 2012; in revised form: 15 June 2012 / Accepted: 20 June 2012 / Published: 27 June 2012
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(This article belongs to the Special Issue Tumor Stroma)
p. 531-548
by  and
Cancers 2012, 4(2), 531-548; doi:10.3390/cancers4020531
Received: 9 April 2012; in revised form: 20 May 2012 / Accepted: 21 May 2012 / Published: 29 May 2012
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(This article belongs to the Special Issue Tumor Stroma)
p. 490-503
by , , , ,  and
Cancers 2012, 4(2), 490-503; doi:10.3390/cancers4020490
Received: 27 February 2012; in revised form: 4 April 2012 / Accepted: 18 April 2012 / Published: 26 April 2012
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(This article belongs to the Special Issue Tumor Stroma)
p. 475-489
by , , , , , ,  and
Cancers 2012, 4(2), 475-489; doi:10.3390/cancers4020475
Received: 27 February 2012; in revised form: 13 April 2012 / Accepted: 13 April 2012 / Published: 25 April 2012
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(This article belongs to the Special Issue Tumor Stroma)
p. 400-419
by  and
Cancers 2012, 4(2), 400-419; doi:10.3390/cancers4020400
Received: 1 March 2012; in revised form: 3 April 2012 / Accepted: 4 April 2012 / Published: 11 April 2012
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(This article belongs to the Special Issue Tumor Stroma)
p. 340-353
by  and
Cancers 2012, 4(2), 340-353; doi:10.3390/cancers4020340
Received: 24 February 2012; in revised form: 20 March 2012 / Accepted: 22 March 2012 / Published: 27 March 2012
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(This article belongs to the Special Issue Tumor Stroma)
p. 4245-4257
by ,  and
Cancers 2011, 3(4), 4245-4257; doi:10.3390/cancers3044245
Received: 11 October 2011; in revised form: 22 November 2011 / Accepted: 30 November 2011 / Published: 8 December 2011
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(This article belongs to the Special Issue Tumor Stroma)
p. 4102-4113
by , , ,  and
Cancers 2011, 3(4), 4102-4113; doi:10.3390/cancers3044102
Received: 8 September 2011; in revised form: 13 October 2011 / Accepted: 21 October 2011 / Published: 31 October 2011
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(This article belongs to the Special Issue Tumor Stroma)
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Last update: 25 February 2014

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