Special Issue "Molecular Mechanisms Underlying Huntington's Disease"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (31 March 2014)
Huntington disease (HD) is a late-onset neurodegenerative disorder that manifests with severe movement disorder, dementia, and psychiatric disturbance. The disease is progressive and invariably fatal and to date there is no cure. HD is a monogenic, autosomal dominant disease. The prevalence for HD varies between different populations and specific HTT haplotypes have been associated with HD in distinct populations. HD is caused by an expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene that encodes a polyglutamine tract in the huntingtin protein (HTT). HD is the most common polyglutamine disorder and is widely accepted as a model disease for studying pathogenic mechanisms and developing therapies in these diseases. HTT is an essential protein that is expressed ubiquitously. However, HD-linked pathogenesis is observed only in the patient’s brains, where N-terminal cleavage fragments of the polyglutamine proteins accumulate into aggregates. The molecular and cellular pathways underlying neurodegeneration in HD are the focus of much research.
The current special issue is meant to collect a selected number of articles that show recent findings in molecular genetics, which could improve our understanding of the pathogenic mechanisms underlying neurodegeneration in HD.
Dr. Sybille Krauss
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Huntington's disease
- polyglutamine proteins
- CAG repeats
- aggregation-prone proteins