Special Issue "Emerging Roles of DNA Repair Enzymes in RNA Metabolism and Gene Expression in Human Cells"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 10 April 2018

Special Issue Editor

Guest Editor
Prof. Dr. Gianluca Tell

Laboratory of Molecular Biology and DNA repair, Department Of Medicine, University of Udine, Piazzale M. Kolbe 4, 33100 Udine, Italy
Website | E-Mail
Interests: base Excision DNA Repair (BER) and cancer; non-canonical roles of DNA repair proteins; DNA damage signaling; proteomics; gene expression

Special Issue Information

Dear Colleagues,

Emerging evidence in cell biology is that RNA processing pathways may participate in DNA Damage Response (DDR), and that defects in these regulatory connections are associated with genomic instability of cancers and neurodegenerative diseases. In fact, many DNA repair proteins are associated with those involved in transcriptional regulation, ncRNA processing and RNA metabolism, in the cytoplasm, nuclei and nucleoli, proving the substantial role of the interactome network in determining their non-canonical functions in human cells. Perhaps, these new insights of DNA repair enzymes, along with their emerging function in RNA-decay, may explain their essential role in tumor development and chemoresistance, as well as in the development of neurodegenerative diseases. The intent of this Special Issue is to summarize the different roles of DNA repair pathways in human cells. The emerging new roles of several DNA repair enzymes in controlling gene expression and RNA metabolism will be highlighted. Although recent works have provided tremendous amount of data in this field, there are still many open questions.

Prof. Dr. Gianluca Tell
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Base Excision Repair
  • DNA Damage Response
  • ncRNA
  • RNA-decay
  • RNA-metabolism
  • miRNA
  • OGG1
  • nucleolus

Published Papers

This special issue is now open for submission.
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