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Applied Sciences
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Bioceramics and Their Applications
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Bioceramics and Their Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (30 November 2018) | Viewed by 9773

Special Issue Editor

Prof. Dr. Piedad N. De Aza

E-Mail Website
Guest Editor
Instituto de Bioingeniería, Universidad Miguel Hernandez, 03202 Elche Alicante, Spain
Interests: designing and developing new polycrystalline biomaterials (dense and porous) with controlled microstructures; making use of appropriated phase equilibrium diagrams and to study, not only their physical properties, but also their behavior in vitro (stem cells) and in vivo (bioactivity in rats and rabbits); the tissue engineering field study of the tissue–ceramic implant interfaces is of particular interest
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioceramics are engineered materials that find their applications in the field of medicine. Traditionally, brittleness, low mechanical fracture toughness and low resistance to impact have limited the applications of the ceramic materials. Nevertheless, a strong interest in the use of ceramics for biomedical engineering applications has been developed from the end of the 20th century. New ceramics, with very improved properties, contributed to increasing the possibilities of using ceramics in biomedicine and their use has extended considerably since then. There is a trend today to more broadly use them as scaffolds for tissue engineering or drug release, as dental implants, or to also use them as particles and microspheres for advanced therapy, which creates unexpected scenarios for patient treatment and rehabilitation. Although there are many other bioceramic technologies and applications. This field is rapidly advancing into new areas of discovery.

It is, therefore, my immense pleasure to invite you to submit a manuscript for this Special Issue, "Bioceramics and Their Applications". Full research articles, short communications and comprehensive review papers covering all aspects of design, processing, characterization, and applications of bioceramics, but not limited to them, will be welcome.

Prof. Piedad N. De Aza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Design

  • Processing

  • Characterization

  • Tissue Engineering

  • Drug delivery

  • Bioactivity

  • Scaffolds

  • Ion release

  • Bioactive bone graft bioceramics

  • Applications

Published Papers (3 papers)

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Research

10 pages, 3602 KiB  
Article
In Vitro Properties for Bioceramics Composed of Silica and Titanium Oxide Composites
by I-Hao Chen, Meng-Jia Lian, Wei Fang, Bo-Rui Huang, Tzu-Hao Liu, Jhih-An Chen, Chih-Ling Huang and Tzer-Min Lee
Appl. Sci. 2019, 9(1), 66; https://doi.org/10.3390/app9010066 - 25 Dec 2018
Cited by 7 | Viewed by 2387
Abstract
It is important for oral and maxillofacial surgeons to repair craniofacial defects on oral cancer patients or patients with congenital problems. Thus, it is a challenge to develop biomaterials that promote bone regeneration as potential materials for bone repair. This work is devoted [...] Read more.
It is important for oral and maxillofacial surgeons to repair craniofacial defects on oral cancer patients or patients with congenital problems. Thus, it is a challenge to develop biomaterials that promote bone regeneration as potential materials for bone repair. This work is devoted to the fabrication of bioceramics composed of silica and titanium oxide with various concentrations of titanium oxide for developing bone repair materials for dentistry and tissue engineering. The silica-based bioceramics were synthesized using the sol–gel method, and titanium oxide was added from the hydrolysis of tetrabutyl titanate. The surface morphology was observed using scanning electron microscopy. The chemical composition was measured using an energy dispersive X-ray spectrometer, and the crystal structure was identified by using an X-ray diffraction diffractometer. The pH value and ion concentrations released in simulated body fluids after immersion with bioceramic samples were measured using a pH meter and inductively coupled plasma mass spectrometry, respectively. In the cell toxicity test, the human osteosarcoma cells (MG63) were used and quantitatively assessed using an MTT assay. The results showed that the proposed bioceramics can be controlled by tuning the Si/Ti ratio to modify the dissolution rate of samples and enhance the formation of apatite. Compared to Dulbecco’s modified Eagle’s medium (DMEM) groups, the cell number of the BG_Ti75 group can be increased to 120%. Furthermore, BG_Ti75 can promote MG63 cell growth with statistical significance and keep the pH value and the released calcium ion concentrations of the soaking environment stable. The proposed bioceramics show potential for bone-regenerating capability. Full article
(This article belongs to the Special Issue Bioceramics and Their Applications)
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8 pages, 6529 KiB  
Article
Preparation and in Vitro Bioactivity of Micron-sized Bioactive Glass Particles Using Spray Drying Method
by Yu-Jen Chou, Chih-Wei Hsiao, Nien-Ti Tsou, Meng-Huang Wu and Shao-Ju Shih
Appl. Sci. 2019, 9(1), 19; https://doi.org/10.3390/app9010019 - 21 Dec 2018
Cited by 16 | Viewed by 3695
Abstract
In recent years, bioactive glasses (BGs) have attracted enormous attention with their superior bioactivity, non-toxicity and degradability. Owing to their properties, they have been applied in various biological applications. In the present work, we demonstrated that micron-sized BGs can be prepared with a [...] Read more.
In recent years, bioactive glasses (BGs) have attracted enormous attention with their superior bioactivity, non-toxicity and degradability. Owing to their properties, they have been applied in various biological applications. In the present work, we demonstrated that micron-sized BGs can be prepared with a spray drying method. This technique offers the advantages of low contamination and the ability of mass production, in contrast to the two major synthetic methods, conventional glass-melting and sol-gel, previously used for preparation of BGs. Characterizations of phase composition, morphology and specific surface area of spray dried BG powders were carried out and bioactivity was examined in vitro with respect to the ability to form a hydroxyapatite layer on the surface of the particles after they were immersed in simulated body fluid. Full article
(This article belongs to the Special Issue Bioceramics and Their Applications)
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13 pages, 5948 KiB  
Article
Impact of a Porous Si-Ca-P Monophasic Ceramic on Variation of Osteogenesis-Related Gene Expression of Adult Human Mesenchymal Stem Cells
by Rabadan-Ros Ruben, Revilla-Nuin Beatriz, Mazón Patricia, Aznar-Cervantes Salvador, Ros-Tarraga Patricia, De Aza Piedad N. and Meseguer-Olmo Luis
Appl. Sci. 2018, 8(1), 46; https://doi.org/10.3390/app8010046 - 01 Jan 2018
Cited by 6 | Viewed by 3316
Abstract
This work evaluates in vitro the influence of a new biocompatible porous Si-Ca-P monophasic (7CaO·P2O5·2SiO2) ceramic on the cellular metabolic activity, morphology and osteogenic differentiation of adult human mesenchymal stem cells (ahMSCs) cultured in basal [...] Read more.
This work evaluates in vitro the influence of a new biocompatible porous Si-Ca-P monophasic (7CaO·P2O5·2SiO2) ceramic on the cellular metabolic activity, morphology and osteogenic differentiation of adult human mesenchymal stem cells (ahMSCs) cultured in basal growth medium and under osteogenic inductive medium. Alamar Blue Assay and FESEM were carried out in order to monitor the cell proliferation and the shape of the cells growing on the Si-Ca-P monophasic ceramic during the study period. The osteogenic differentiation of ahMSCs was investigated by means of immunofluorescent staining (osteocalcin, osteopontin, heparan sulphate and collagen type I expression), quantitative reverse transcription polymerase chain reaction (qRT-PCR) (integrin-binding sialoprotein, osteocalcin, alkaline phosphatase, osteopontin, osteonectin, runt-related transcription factor 2 and collagen type I) and expression of surface markers (CD73, CD90 and CD105). We could check osteogenic differentiation in ahMSCs growing under the influence of Si-Ca-P monophasic ceramics itself, but especially when growth medium was replaced by osteogenic medium in the culture conditions. These results allowed us to conclude that the new Si-Ca-P monophasic scaffold greatly enhanced ahMSCs proliferation and osteogenic differentiation; therefore, it may be considered to be employed as a new bone graft substitute or scaffold for bone tissue engineering. Full article
(This article belongs to the Special Issue Bioceramics and Their Applications)
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