Special Issue "Lipid Peroxidation: Analysis and Applications in Biological Systems"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 September 2018

Special Issue Editors

Guest Editor
Dr. Jetty Chung-Yung Lee

The University of Hong Kong School of Biological Sciences Pokfulam Road, Hong Kong
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Interests: Oxidised products of omega-3 and omega-6 fatty acids (oxylipins) and lipid mediator profiling of biological samples; Antioxidant and oxidative stress in human nutrition; Oxidative stress and disease development; Development and measurement of oxidative damage biomarkers in biological samples using mass spectrometry; Oxidative stress and environmental stressors
Guest Editor
Dr. Thierry Durand

Directeur de Recherche CNRSInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, Université de Montpellier, ENSCM, France
Website | E-Mail
Interests: Total synthesis of bioactive lipids (iso-, phyto- and neuroprostanes, iso-, phyto and neurofurans, lipophenols, protectins, FAHFA); Quantification of isoprostanoids in biological fluids and vegetable matrixs, using LC-MS; Oxidative stress and disease development

Special Issue Information

Dear Colleagues,

It is globally known the interaction of free radical/reactive oxygen species (ROS) in lipid metabolism, namely polyunsaturated fatty acids are the core source of lipid peroxidation reaction in the biological systems. The metabolites released can be biomarkers of oxidative stress such as isoprostanes in mammals and phytoprostanes in plants and food or act as mediators in signalling pathways to redox responses, and even displayed some health benefits. Collectively, they are also known as oxylipins and are ubiquitous in the living system. In retrospect, antioxidants have been known for decades to regulate the release of these metabolites and prevent progression of diseases, and recently, phytochemicals tandem fatty acids including lipophenols showed potent antioxidant properties. However, proper selection of analysis for valid evaluation of antioxidant potential in desired applications is needed to understand the principle mechanisms of these oxylipins including synthesis, distribution, metabolism, and excretion in plants and mammals.

This Special Issue will publish original research papers and reviews on aspects of oxylipins derived from polyunsaturated fatty acids related to the following topics: health and diseases, metabolism, antioxidants, analytical views, chemistry and biomarkers.

  • Oxylipins
  • Isoprostanes
  • Phytoprostanes
  • Polyunsaturated fatty acids
  • Lipophenols 
  • Mass spectrometry

Dr. Jetty Chung-Yung Lee
Dr. Thierry Durand
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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Open AccessArticle Profiling of Omega-Polyunsaturated Fatty Acids and Their Oxidized Products in Salmon after Different Cooking Methods
Antioxidants 2018, 7(8), 96; https://doi.org/10.3390/antiox7080096
Received: 5 June 2018 / Revised: 13 July 2018 / Accepted: 14 July 2018 / Published: 24 July 2018
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Abstract
Consumption of food containing n-3 PUFAs, namely EPA and DHA, are known to benefit health and protect against chronic diseases. Both are richly found in marine-based food such as fatty fish and seafood that are commonly cooked prior to consumption. However, the elevated
[...] Read more.
Consumption of food containing n-3 PUFAs, namely EPA and DHA, are known to benefit health and protect against chronic diseases. Both are richly found in marine-based food such as fatty fish and seafood that are commonly cooked prior to consumption. However, the elevated temperature during cooking potentially degrades the EPA and DHA through oxidation. To understand the changes during different cooking methods, lipid profiles of raw, boiled, pan-fried and baked salmon were determined by LC-MS/MS. Our results showed that pan-frying and baking elevated the concentration of peroxides in salmon, whereas only pan-frying increased the MDA concentration, indicating it to be the most severe procedure to cause oxidation among the cooking methods. Pan-frying augmented oxidized products of n-3 and n-6 PUFAs, while only those of n-3 PUFA were elevated in baked salmon. Notably, pan-frying and baking increased bioactive oxidized n-3 PUFA products, in particular F-4t-neuroprostanes derived from DHA. The results of this study provided a new insight into the application of heat and its effect on PUFAs and the release of its oxidized products in salmon. Full article
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
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Review

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Open AccessReview Isoprostanoids in Clinical and Experimental Neurological Disease Models
Antioxidants 2018, 7(7), 88; https://doi.org/10.3390/antiox7070088
Received: 13 June 2018 / Revised: 28 June 2018 / Accepted: 9 July 2018 / Published: 11 July 2018
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Abstract
Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA. Although they were discovered about a quarter of century ago, the
[...] Read more.
Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA. Although they were discovered about a quarter of century ago, the knowledge on the role of key isoprostanoids in the pathogenesis of experimental and human disease models remains limited. This is mainly due to the limited availability of highly purified molecules to be used as a reference standard in the identification of biological samples. The accurate knowledge on their biological relevance is the critical step that could be translated from some mere technical/industrial advances into a reliable biological disease marker which is helpful in deciphering the oxidative stress puzzle related to neurological disorders. Recent research indicates the value of isoprostanoids in predicting the clinical presentation and evolution of the neurological diseases. This review focuses on the relevance of isoprostanoids as mediators and potential biomarkers in neurological diseases, a heterogeneous family ranging from rare brain diseases to major health conditions that could have worldwide socioeconomic impact in the health sector. The current challenge is to identify the preferential biochemical pathways that actually follow the oxidative reactions in the neurological diseases and the consequence of the specific isoprostanes in the underlying pathogenic mechanisms. Full article
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
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