Special Issue "Computational Antibody and Antigen Design"

A special issue of Antibodies (ISSN 2073-4468).

Deadline for manuscript submissions: 30 April 2018

Special Issue Editor

Guest Editor
Dr. Buyong Ma

Basic Science Program, Leidos Biomedical Research, Inc., Cancer and Inflammation Program, National Cancer Institute, NIH, Frederick, MD 21702, USA
E-Mail
Interests: Computational chemistry and biology; Computational Immunology; Protein-Protein Interaction; Protein aggregation diseases; Neurodegenerative disease; Alzheimer's Disease; Cancer and Inflammation; Antigen receptors and signaling; Antibody design

Special Issue Information

Dear Colleagues,

Using computational modeling to help antibody engineering is complementary to traditional animal models and phage display methodologies, hopefully speeding up and providing additional variations into antibody design. Starting from antibody/antigen sequences, one can model the structures of antibody and antigen, predict antibody–antigen interactions through docking and/or molecular dynamics simulations, and provide computationally designed/optimized systems for experimental verification. Computational antibody design can lead to high affinity, high stability, and high specificity. In vaccine design, computational modeling can generate small and stable protein scaffolds, mimicking antigen epitopes to induce potent neutralizing antibodies. Even with this promising power, widely-integrated application of computational modeling in antibody engineering is still yet to arrive. This Special Issue will showcase various aspects of computational antibody and antigen design.

This Special Issue of Antibodies focuses on: (1) computational/structural characterization of antibody structures; (2) bioinformatics study of antibody and antigens; (3) computational algorithms in antibody and antigen design; and (4) applications of computational methods in antibody/antigen development. 

Dr. Buyong Ma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibody design
  • antibody engineering
  • vaccine design
  • protein-protein interaction
  • computational biology

Published Papers

This special issue is now open for submission.
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