Abstract: In this paper (R)-7-(azepan-3-ylamino)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride 1 was isolated and identified as the N-substituted regioisomer of besifloxacin, which has been synthesized from the reaction of 8-chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 3 with (R)-tert-butyl 3-aminoazepane-1-carboxylate 2 in acetonitrile as solvent in 37% yield. The chemical structure of compound 1 was established on the basis of 1H-NMR, 13C-NMR, mass spectrometry data and elemental analysis.
Abstract: S-Alkylation of 5-(diphenylmethyl)-1,3,4-oxadiazole-2(3H)-thione (3) by 2-chloro-N-(pyrazin-2-yl)acetamide (2) affords the title compound, 2-{[5-(diphenylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(pyrazin-2-yl)acetamide (4). The intermediate (2), in turn, was prepared by the acetylation of 2-aminopyrazine (1) with chloroacetyl chloride. The structure of the newly synthesized compound is characterized by IR, NMR and mass spectral data.
Abstract: 3,3'-(1,4-Phenylenebis(phenylazanediyl))bis(7-ethoxy-4-methyl-2H-chromen-2-one) was synthesized from N,N'-diphenylbenzene-1,4-diamine and bromo-7-ethoxy-4-methylcoumarin based on Ullmann coupling reaction. The synthesized compound was characterized by UV-Visible, NMR, FT-IR, MS, elemental analysis and Fluorescence Spectrum.
Abstract: A novel synthetic methodology for preparation of thiocarbohydrazone by reacting thiocarbohydrazide with 1-acetyl-5-chloroisatin is described. The title compound was prepared by condensation of thiocarbohydrazide and substituted isatin in aqueous ethanol. The newly synthesized compound was characterized using 1H-NMR, 13C-NMR, FT-IR and mass spectrometry.
Abstract: The title compound, 2-chloro-7-methyl-3-({4-[(4-nitrophenoxy)methyl]-1H-1,2,3-triazol-1-yl}methyl)quinoline was synthesized in one pot. The structure of the compound was fully characterized by IR, 1H and 13C-NMR, mass spectral analysis and elemental analysis.
Abstract: Diels Alder reaction of 4-bromophenylquinone (Br-PQ) with anthracene, followed by reduction affords the desired 4'-bromophenyl triptycene-2,5-diol (T-Br-PH). The described synthesis represents a simple and efficient method for the construction of a triptycene ring with a bromophenyl pendant. The intermediate and the final compound (T-Br-PH) have been characterized by elemental analysis, NMR, and LCMS techniques.
