Abstract: It gives me great pleasure to welcome you to Chemosensors, a new online-only journal established by the Multidisciplinary Digital Publishing Institute (MDPI, Basel, Switzerland) with the intent of covering all aspects of chemical sensing. The ability to sense or detect/identify and quantitate a chemical entity, and in particular accomplish this through the use of chemical means, has never been a more important part of our society. Chemosensing permeates diverse fields including healthcare (e.g., blood chemistry analysis), food safety (e.g., detecting contamination and spoilage), environmental monitoring (e.g., air and water quality), product and manufacturing assurance (e.g., purity and efficacy), household safety (e.g., smoke detection), forensics (e.g., drug analysis), and biological research (e.g., quantitating DNA or monitoring intracellular homeostasis), to name but a paltry few areas. Indeed, the application of chemosensing has become such an integrated aspect of modern society that trying to compile a comprehensive list of where it is utilized or relied on is almost impossible. Equally daunting is trying to compile a comprehensive list of all the different sensing techniques, types of analysis, modes of signal transduction, instruments and similar type aspects. The pace of new developments in this field is both remarkable and continuously accelerating with new products and applications being developed on an almost unceasing basis. [...]