Appl. Sci.2015, 5(1), 36-47; doi:10.3390/app5010036 - published 17 February 2015 Show/Hide Abstract
Abstract: Direct laser acceleration of ions by short frequency chirped laser pulses is investigated theoretically. We demonstrate that intense beams of ions with a kinetic energy broadening of about 1% can be generated. The chirping of the laser pulse allows the particles to gain kinetic energies of hundreds of MeVs, which is required for hadron cancer therapy, from pulses of energies in the order of 100 J. It is shown that few-cycle chirped pulses can accelerate ions more efficiently than long ones, i.e., higher ion kinetic energies are reached with the same amount of total electromagnetic pulse energy.
Appl. Sci.2015, 5(1), 23-35; doi:10.3390/app5010023 - published 13 February 2015 Show/Hide Abstract
Abstract: Vibrational spectroscopy analyses vibrations within a molecule and can be used to characterise a molecular structure. Raman spectroscopy is one of the vibrational spectroscopic techniques, in which incident radiation is used to induce vibrations in the molecules of a sample, and the scattered radiation may be used to characterise the sample in a rapid and non-destructive manner. Infrared (IR) spectroscopy is a complementary vibrational spectroscopic technique based on the absorption of IR radiation by the sample. Molecules absorb specific frequencies of the incident light which are characteristic of their structure. IR and Raman spectroscopy are sensitive to subtle biochemical changes occurring at the molecular level allowing spectral variations corresponding to disease onset to be detected. Over the past 15 years, there have been numerous reports demonstrating the potential of IR and Raman spectroscopy together with multivariate statistical analysis techniques for the detection of a variety of cancers including, breast, lung, brain, colon, oral, oesophageal, prostate and cervical cancer. This paper discusses the recent advances and the future perspectives in relation to cancer screening applications, focussing on cervical and oral cancer.
Appl. Sci.2015, 5(1), 1-20; doi:10.3390/app5010001 - published 29 December 2014 Show/Hide Abstract
Abstract: We present a new external-beam radiation therapy system using very-high-energy (VHE) electron/photon beams generated by a centimeter-scale laser plasma accelerator built in a robotic system. Most types of external-beam radiation therapy are delivered using a machine called a medical linear accelerator driven by radio frequency (RF) power amplifiers, producing electron beams with an energy range of 6–20 MeV, in conjunction with modern radiation therapy technologies for effective shaping of three-dimensional dose distributions and spatially accurate dose delivery with imaging verification. However, the limited penetration depth and low quality of the transverse penumbra at such electron beams delivered from the present RF linear accelerators prevent the implementation of advanced modalities in current cancer treatments. These drawbacks can be overcome if the electron energy is increased to above 50 MeV. To overcome the disadvantages of the present RF-based medical accelerators, harnessing recent advancement of laser-driven plasma accelerators capable of producing 1-GeV electron beams in a 1-cm gas cell, we propose a new embodiment of the external-beam radiation therapy robotic system delivering very high-energy electron/photon beams with an energy of 50–250 MeV; it is more compact, less expensive, and has a simpler operation and higher performance in comparison with the current radiation therapy system.
Appl. Sci.2014, 4(4), 525-547; doi:10.3390/app4040525 - published 28 November 2014 Show/Hide Abstract
Abstract: We review the thermal properties of graphene, few-layer graphene and graphene nanoribbons, and discuss practical applications of graphene in thermal management and energy storage. The first part of the review describes the state-of-the-art in the graphene thermal field focusing on recently reported experimental and theoretical data for heat conduction in graphene and graphene nanoribbons. The effects of the sample size, shape, quality, strain distribution, isotope composition, and point-defect concentration are included in the summary. The second part of the review outlines thermal properties of graphene-enhanced phase change materials used in energy storage. It is shown that the use of liquid-phase-exfoliated graphene as filler material in phase change materials is promising for thermal management of high-power-density battery parks. The reported experimental and modeling results indicate that graphene has the potential to outperform metal nanoparticles, carbon nanotubes, and other carbon allotropes as filler in thermal management materials.
Appl. Sci.2014, 4(4), 515-524; doi:10.3390/app4040515 - published 26 November 2014 Show/Hide Abstract
Abstract: We report a multi-watt broadband continuous-wave multi-harmonic optical comb based on a frequency division-by-three singly-resonant optical parametric oscillator. This cw optical comb is frequency-stabilized with the help of a beat signal derived from the signal and frequency-doubled idler waves. The measured frequency fluctuation in one standard deviation is ~437 kHz. This is comparable to the linewidth of the pump laser which is a master-oscillator seeded Yb:doped fiber amplifier at ~1064 nm. The measured powers of the fundamental wave and the harmonic waves up to the 6th harmonic wave are 1.64 W, 0.77 W, 3.9 W, 0.78 W, 0.17 W, and 0.11 W, respectively. The total spectral width covered by this multi-harmonic comb is ~470 THz. When properly phased, this multi-harmonic optical comb can be expected to produce by Fourier synthesis a light source consisting of periodic optical field waveforms that have an envelope full-width at half-maximum of 1.59 fs in each period.