This meeting will bring together researchers who study how viruses manipulate cellular processes for their own replication focusing on how viruses perturb nuclear functions. The scope will be broad and will embrace diverse virus families, including DNA viruses that replicate in the nucleus, such as Polyoma-,Papilloma-, Adeno- and Herpesviruses, extending to HIV, retroviruses and nuclear RNA viruses, like Influenza. Also included will be RNA viruses that replicate in the cytoplasm but exploit or hijack nuclear functions. Topics will include subversion of host transcriptional machinery; effects on host DNA repair pathways; epigenetic alterations; viral remodeling of the nucleus; viral induction of the stress response, immune evasion and innate antiviral defense, miRNA regulation; viral effects on the nuclear membrane, and viruses and cancer. The goal of the conference is to integrate discussions on how different viruses have developed strategies to target host nuclear functions.