Metabolic Pathway Analysis (MPA) 2017 will be held July 24-28, 2017 at Montana State University (MSU), Bozeman. The MPA conference series is one of the preeminent international meetings for the scientific community analyzing the topological structure-function relationships of metabolic networks. MPA 2017 will focus on computational approaches to decode biological principles found in ‘omics’ data sets and will span the gamut of fundamental and applied biology including biofuels, photosynthesis, multicellular systems, environmental nutrient cycles, and human health. The MPA conference series integrates a highly interdisciplinary group of international biologists, computer scientists, engineers and mathematicians for formal and informal discussions focused on state-of-the-art advances in metabolic network analysis methodology, theory and application. MPA 2017 will be the sixth conference in the biennial conference series and will be the first MPA conference held in North America.