Special Issue "Fungal Metabolites"

A special issue of Agriculture (ISSN 2077-0472).

Deadline for manuscript submissions: closed (30 June 2016)

Special Issue Editors

Guest Editor
Dr. Anna Andolfi

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo Via Cintia 4, I-80126 Naples, Italy
Website | E-Mail
Phone: +39 081 2539179
Interests: secondary metabolites in plant-pathogen interaction; natural substances with biological activity; chromatographic techniques, spectroscopic methods
Guest Editor
Dr. Rosario Nicoletti

Council for Agricultural Research and Economics. Current address: Department of Agricultural Sciences, Universiy of Naples Federico II, Via Università 100, 80055 Portici, Italy
Website | E-Mail
Interests: bioactive metabolites; drug discovery; endophytes; marine-facultative fungi; Penicillium

Special Issue Information

Dear Colleagues,

With an estimated number of about 1.5 milion species, fungi are among the most widespread organisms on Earth. They are known to be able to adapt to almost all ecological niches in any environment, where they play many different roles as saprophytes, pathogens, predators, parasites, hosts, and/or symbionts.

Such an adaptability is reflected by their capacity to produce a wide array of secondary metabolites. Mycotoxins, phytotoxins, plant growth regulators, antibiotics, insecticides, enzyme inhibitors, etc., are not essential for the survival of the producing organism, but exert a fundamental role for its development. Thus far, the ecological significance and the biological effects of the majority of such compounds have not been adequately elucidated. Moreover, gradual global warming is modifying the geographical distribution of many species, with possible, ensuing, and significant modifications in their metabolic profiles.

The great interest of the scientific community in these compounds derives from the opportunity to identify products to be used in human medicine, in agriculture, and in industry, such as drugs, pesticides, and raw materials. The very large progress made in the field of mycology, genetics, and organic and analytical chemistry have enabled researchers to use more sophisticated techniques for culturing fungi, for their taxonomic identification, for biological assays, for the isolation, structural and stereo-structural characterization of novel bioactive metabolites, and for their rapid detection in vitro and in vivo. Further implications are often derived in view of resorting to synthetic methods for mass production of the active target molecules.

This Special Issue is destined to gather reviews and original experimental papers on all the above-reported aspects, in the expectation that it may serve as a boost for a further development of knowledge in this fascinating and continuously evolving research field.

Dr. Anna Andolfi
Dr. Rosario Nicoletti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Agriculture is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • fungal secondary metabolites
  • bioactive compounds
  • structure elucidation
  • bioassays
  • chemotaxonomy

Published Papers (1 paper)

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Open AccessReview Fungal Metabolites for the Control of Biofilm Infections
Agriculture 2016, 6(3), 37; doi:10.3390/agriculture6030037
Received: 24 June 2016 / Revised: 1 August 2016 / Accepted: 9 August 2016 / Published: 12 August 2016
Cited by 2 | PDF Full-text (3464 KB) | HTML Full-text | XML Full-text
Many microbes attach to surfaces and produce a complex matrix of polymers surrounding their cells, forming a biofilm. In biofilms, microbes are much better protected against hostile environments, impairing the action of most antibiotics. A pressing demand exists for novel therapeutic strategies against
[...] Read more.
Many microbes attach to surfaces and produce a complex matrix of polymers surrounding their cells, forming a biofilm. In biofilms, microbes are much better protected against hostile environments, impairing the action of most antibiotics. A pressing demand exists for novel therapeutic strategies against biofilm infections, which are a grave health wise on mucosal surfaces and medical devices. From fungi, a large number of secondary metabolites with antimicrobial activity have been characterized. This review discusses natural compounds from fungi which are effective against fungal and bacterial biofilms. Some molecules are able to block the cell communication process essential for biofilm formation (known as quorum sensing), others can penetrate and kill cells within the structure. Several targets have been identified, ranging from the inhibition of quorum sensing receptors and virulence factors, to cell wall synthesizing enzymes. Only one group of these fungal metabolites has been optimized and made it to the market, but more preclinical studies are ongoing to expand the biofilm-fighting arsenal. The broad diversity of bioactive compounds from fungi, their activities against various pathogens, and the multi-target trait of some molecules are promising aspects of fungal secondary metabolites. Future screenings for biofilm-controlling compounds will contribute to several novel clinical applications. Full article
(This article belongs to the Special Issue Fungal Metabolites)

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