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The History of the Decline and Fall of the Glial Numbers Legend
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Neuroglia 2018, 1(1), 193-219; https://doi.org/10.3390/neuroglia1010014

You Do Not Mess with the Glia

1
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
2
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37240, USA
3
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240-7817, USA
*
Author to whom correspondence should be addressed.
Received: 8 June 2018 / Revised: 28 June 2018 / Accepted: 3 July 2018 / Published: 17 July 2018
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Abstract

Vertebrate neurons are enormously variable in morphology and distribution. While different glial cell types do exist, they are much less diverse than neurons. Over the last decade, we have conducted quantitative studies of the absolute numbers, densities, and proportions at which non-neuronal cells occur in relation to neurons. These studies have advanced the notion that glial cells are much more constrained than neurons in how much they can vary in both development and evolution. Recent evidence from studies on gene expression profiles that characterize glial cells—in the context of progressive epigenetic changes in chromatin during morphogenesis—supports the notion of constrained variation of glial cells in development and evolution, and points to the possibility that this constraint is related to the late differentiation of the various glial cell types. Whether restricted variation is a biological given (a simple consequence of late glial cell differentiation) or a physiological constraint (because, well, you do not mess with the glia without consequences that compromise brain function to the point of rendering those changes unviable), we predict that the restricted variation in size and distribution of glial cells has important consequences for neural tissue function that is aligned with their many fundamental roles being uncovered. View Full-Text
Keywords: evolution; glia/neuron ratio; glial density; cell size evolution; glia/neuron ratio; glial density; cell size
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Herculano-Houzel, S.; Dos Santos, S.E. You Do Not Mess with the Glia. Neuroglia 2018, 1, 193-219.

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