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Colloids Interfaces 2018, 2(1), 6; doi:10.3390/colloids2010006

Acetonitrile-Induced Destabilization in Liposomes

1
Department of Mechanical Systems Engineering, Graduate School of Science and Engineering Yamagata University, 4-3-16, Jonan, Yonezawa, Yamagata 992-8510, Japan
2
Department of Physics and Mathematics, College of Science and Engineering, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan
*
Author to whom correspondence should be addressed.
Received: 25 January 2018 / Revised: 8 February 2018 / Accepted: 8 February 2018 / Published: 11 February 2018
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Abstract

To understand the behavior of cellular interfaces, it is important to clarify the effect of chemical compounds on artificial cell membranes. In this study, an aqueous acetonitrile solution was mixed with a suspension of lipid vesicles, and the changes in vesicle behavior arising as a result of acetonitrile application were observed. The fast Fourier transformations (FFTs) of the membrane waviness/crinkliness of the vesicles were carried out, and the membrane thermal fluctuations were analyzed. The experimental results show that the addition of acetonitrile molecules enhances the fluctuation of lipid membranes. In particular, the k = 2 mode fluctuation was significantly enhanced. This finding is expected to lead us to a further understanding of the fundamental properties of living cells. View Full-Text
Keywords: artificial cellular interface; membrane fluctuation; optical microscopy artificial cellular interface; membrane fluctuation; optical microscopy
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Yoshida, K.; Mitsumori, R.; Horii, K.; Takashima, A.; Nishio, I. Acetonitrile-Induced Destabilization in Liposomes. Colloids Interfaces 2018, 2, 6.

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