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J. Compos. Sci. 2017, 1(2), 15; doi:10.3390/jcs1020015

Effect of the Chemical Composition of Simulated Body Fluids on Aerogel-Based Bioactive Composites

Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1 H-4032, Hungary
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Received: 16 October 2017 / Revised: 12 November 2017 / Accepted: 23 November 2017 / Published: 27 November 2017
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Abstract

Replacement of damaged or missing bone tissue is a serious problem in orthopedic surgery. Although various artificial materials are available, none of them fulfil the requirements completely. In this study, new bone substitute materials, silica aerogel-based β-tricalcium phosphate, and hydroxyapatite composite ceramics, along with a control sample were synthesized and tested. Porosities and pore size distribution curves were determined by nitrogen gas adsorption/desorption porosimetry, and surface morphology changes were studied by scanning electron microscopy. Bioactivities were tested in vitro by soaking the samples in simulated body fluids (SBF). Three new advanced SBFs containing eight essential amino acids and bovine serum albumin were developed, extending the complexity of the original simulated body fluid in order to approximate the human blood plasma’s composition more accurately. Each sample was treated with SBF1–SBF4 for two weeks. According to our results, it seems to be necessary to re-evaluate hydroxyapatite deposition as proof of bioactivity of artificial bone substitutes when synthetic body fluids analogous in their composition to human blood plasma are used in studies. View Full-Text
Keywords: silica aerogel-based bioceramics; artificial bone substitute composite; simulated body fluid; assessment of bioactivity; hydroxyapatite deposition silica aerogel-based bioceramics; artificial bone substitute composite; simulated body fluid; assessment of bioactivity; hydroxyapatite deposition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Győri, E.; Fábián, I.; Lázár, I. Effect of the Chemical Composition of Simulated Body Fluids on Aerogel-Based Bioactive Composites. J. Compos. Sci. 2017, 1, 15.

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J. Compos. Sci. EISSN 2504-477X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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