Next Article in Journal
Steps towards Industrial Validation Experiments
Previous Article in Journal
Characterization of the Modal Parameters of Composite Laminates Using Innovative Ultrathin Polymer Waveguide Sensor Foils
Article Menu
Issue 8 (ICEM 2018) cover image

Article Versions

Export Article

Open AccessProceedings
Proceedings 2018, 2(8), 388;

3D Modeling of Plaque Progression in the Human Coronary Artery

Faculty of Engineering, University of Kragujevac, 34000 Kragujevac, Serbia
Bioengineering Research and Development Center, 34000 Kragujevac, Serbia
National Research Council Pisa, 56124 Pisa, Italy
Presented at the 18th International Conference on Experimental Mechanics, Brussels, Belgium, 1–5 July 2018.
Author to whom correspondence should be addressed.
Published: 9 May 2018
PDF [1042 KB, uploaded 5 June 2018]


The inflammation and lipid accumulation in the arterial wall represents a progressive disease known as atherosclerosis. In this study, a numerical model of atherosclerosis progression was developed. The wall shear stress (WSS) and blood analysis data have a big influence on the development of this disease. The real geometry of patients, and the blood analysis data (cholesterol, HDL, LDL, and triglycerides), used in this paper, was obtained within the H2020 SMARTool project. Fluid domain (blood) was modeled using Navier-Stokes equations in conjunction with continuity equation, while the solid domain (arterial wall) was modeled using Darcy’s law. For the purpose of modeling low-density lipoprotein (LDL) and oxygen transport, convection-diffusion equations were used. Kedem-Katchalsky equations were used for coupling fluid and solid dynamics.
Keywords: low-density lipoprotein; coronary artery; plaque concentration; wall shear stress low-density lipoprotein; coronary artery; plaque concentration; wall shear stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Saveljic, I.; Nikolic, D.; Milosevic, Z.; Isailovic, V.; Nikolic, M.; Parodi, O.; Filipovic, N. 3D Modeling of Plaque Progression in the Human Coronary Artery. Proceedings 2018, 2, 388.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top