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Proceedings 2017, 1(4), 604; doi:10.3390/proceedings1040604

Low-Cost Impedance Measurements for Lab-on-a-Chip Architectures: Towards Potentiostat Miniaturization

1
Departament d’Enginyeries: Electrònica, Universitat de Barcelona, E-08028 Barcelona, Spain
2
Institut des Sciences Analytiques, Université de Lyon 1, UMR 5280, CNRS, F-69100 Villeurbanne, France
3
Centro Nacional de Microelectrónica (IMB-CSIC), Campus UAB, Bellaterra, 08193 Barcelona, Spain
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 28 August 2017
(This article belongs to the Proceedings of Eurosensors 2017)
Download PDF [473 KB, uploaded 28 August 2017]

Abstract

The development of miniaturized potentiostats capable of measuring in a wide range of conditions and with full characteristics (e.g., wide bandwidth and capacitive/inductive contribution to sensor’s impedance) is still an unresolved challenge in bioelectronics. We present a simple analogue design coupled to a digital filter based on a lock-in amplifier as an alternative to complex architectures reported hitherto. A low-cost, miniaturized and fully integrated acquisition electronic system was developed, tested for a fully integrated three-lead electrochemical biosensor and benchmarked against a commercial potentiostat. The portable potentiostat was coupled to an array of miniaturized gold working electrodes to perform complex impedance analyses for tumor necrosis factor α (TNF-α) cytokine detection. This wearable potentiostat is very promising for the development of low-cost point-of-care (POC) with low power consumption.
Keywords: point of care; electrochemical impedance spectroscopy; miniaturized potentiostat; heart failure; lab-on-a-chip; TNF-α point of care; electrochemical impedance spectroscopy; miniaturized potentiostat; heart failure; lab-on-a-chip; TNF-α
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pruna, R.; Palacio, F.; Baraket, A.; Bausells, J.; Errachid, A.; López, M. Low-Cost Impedance Measurements for Lab-on-a-Chip Architectures: Towards Potentiostat Miniaturization. Proceedings 2017, 1, 604.

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