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Proceedings 2017, 1(4), 536; doi:10.3390/proceedings1040536

Leishmania spp. Detection Using a Surface Plasmon Resonance Biosensor

1
Human Immunology Research and Education Group, Universidade Federal da Paraíba, 58051-900 PB, Brazil
2
Institute of Genetics and Biochemistry. Universidade Federal de Uberlândia, Uberlândia, 38408-100 MG, Brazil
3
Clinical and Social Dentistry Department, Universidade Federal da Paraíba, Joao Pessoa, 58051-900 PB, Brazil
4
Materials Science Engineering Department, Universidade Federal da Paraíba, Joao Pessoa, 58051-900 PB, Brazil
5
Electrical Engineering Department. Universidade Federal de Campina Grande, 58051-900 Paraiba, Brazil
6
Universidade Federal Rural do Semi-Árido, Angicos, 59515-000 RN, Brazil
7
Université de Lorraine, 54000 Nancy, France
8
Electrical Engineering Department. Instituto Federal da Paraiba, Joao Pessoa, 58800-970 PB, Brazil
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 9 August 2017
Download PDF [459 KB, uploaded 10 August 2017]

Abstract

The detection of Leishmania spp. through a disposable surface plasmon resonance (SPR) biochip, using mono- and polychromatic sources, is presented here. A highly specific and sensitive-constrained synthetic peptide (LC2) derived from a mimotope of Leishmania chagasi antigen was immobilized on the sensing region using a simple protocol. ELISA- and PCR-confirmed negative and positive sera of Leishmania chagasi infected patients were used. Detection of positive IgG showed a fast response with good sensitivity and specificity for the proposed method.
Keywords: Leishmania spp.; surface plasmon resonance; fast diagnosis; biosensor Leishmania spp.; surface plasmon resonance; fast diagnosis; biosensor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ferreira, E.; Lima, J.; Alves-Balvedi, R.P.; Bonan, P.R.; Medeiros, E.; Goulart, L.; Lima, A.; Neff, H.; Oliveira, L.; Castellano, L.; Araújo, A.; Moreira, C. Leishmania spp. Detection Using a Surface Plasmon Resonance Biosensor. Proceedings 2017, 1, 536.

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