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Proceedings 2017, 1(4), 528; doi:10.3390/proceedings1040528

Novel Four Layer Metal Sensing in Portable SPR Sensor Platform for Viral Particles Quantification

Department of Electronic Engineering, Chang-Gung University, Taoyuan City 33302, Taiwan
Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan
Indonesian Institute of Sciences, Bandung 40135, Indonesia
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
Author to whom correspondence should be addressed.
Published: 21 August 2017
(This article belongs to the Proceedings of Eurosensors 2017)
Download PDF [492 KB, uploaded 21 August 2017]


Label-free, direct, rapid and real-time quantification method for human enterovirus 71 (EV71) using surface plasmon resonance (SPR) sensor is presented in this study. The performance of the four layer sensor chip was compared with the conventional Au monolayer sensor chip. Four layer sensor chip gave optimum resonance wavelength around 610 nm, which was same with the OLED light source peak wavelength and gave better quality factor (Q = DIP/FWHM). The result showed that the structure with 3 nm Al, 10 nm Au, 20 nm Ag, 10 nm Au layer sensor chip gave better limit of detection than the 3 nm Cr, and 47 nm Au layer sensor chip. The detection limit of direct quantification of EV71 particles is improved to 43 vp/mL of EV71 in DMEM medium. The results proved that the SPR biosensor with four layer sensor chip structure demonstrated great performance in the quantification of EV71 virus species.
Keywords: SPR sensor; four layer sensor chip; EV71 virus; quantification; OLED SPR sensor; four layer sensor chip; EV71 virus; quantification; OLED
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Prabowo, B.A.; Alom, A.; Pal, P.; Secario, M.K.; Wang, R.Y.L.; Liu, K.C. Novel Four Layer Metal Sensing in Portable SPR Sensor Platform for Viral Particles Quantification. Proceedings 2017, 1, 528.

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