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Proceedings 2017, 1(4), 518; doi:10.3390/proceedings1040518

Differential Inductive Sensor for Continuous Non-Invasive Cell Growth Monitoring in Disposable Bioreactors

1
Department of Sensors and Measurement Technology, Institute of Electrical Engineering and Measurement Technology, Leibniz Universität Hannover, Hannover, Germany
2
Institute of Technical Chemistry, Leibniz Universität Hannover, Hannover, Germany
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 17 August 2017
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Abstract

In this work, we present a low-cost sensor system for continuous non-invasive cell growth monitoring, especially for single use bioreactor (SUB) applications. The sensor system is based on a differential transformer. Using this differential setup, the influence of the primary magnetic flux is eliminated from the measuring signal, enabling highly sensitive non-invasive detection of permittivity changes in the culture medium. To evaluate the sensor, E. coli cultivations are performed and the cell density is measured through the polymer foil of a SUB. We found a linear dependency with low data scattering between measuring signal and cell density.
Keywords: cell growth monitoring; single use bioreactor; inductive permittivity measurements; dielectric spectroscopy; differential transformer cell growth monitoring; single use bioreactor; inductive permittivity measurements; dielectric spectroscopy; differential transformer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Allers, M.; Reinecke, T.; Nagraik, T.; Solle, D.; Bakes, K.; Berger, M.; Scheper, T.; Zimmermann, S. Differential Inductive Sensor for Continuous Non-Invasive Cell Growth Monitoring in Disposable Bioreactors. Proceedings 2017, 1, 518.

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