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Proceedings 2017, 1(4), 505; doi:10.3390/proceedings1040505

Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier

1
Institute of Nano- and Biotechnologies, FH Aachen, Campus Jülich, 52428 Jülich, Germany
2
Institute of Biomaterials and Biomolecular Systems, Universität Stuttgart, 70569 Stuttgart, Germany
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Authors to whom correspondence should be addressed.
Published: 8 August 2017
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Abstract

A new concept for the development of semiconductor field-effect biosensors by modification of a gate surface with tobacco mosaic virus (TMV) nanotubes, serving as enzyme nanocarrier, is presented. TMV nanotubes enable an immobilization of a high amount of enzymes without substantial loss of their activity, resulting in an enhanced biosensor performance. This approach has been experimentally demonstrated by realizing a capacitive field-effect penicillin biosensor using TMV nanotubes functionalized with the enzyme penicillinase as model system.
Keywords: field-effect sensor; penicillin biosensor; enzyme penicillinase; tobacco mosaic virus; enzyme nanocarrier field-effect sensor; penicillin biosensor; enzyme penicillinase; tobacco mosaic virus; enzyme nanocarrier
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jablonski, M.; Koch, C.; Bronder, T.S.; Poghossian, A.; Wege, C.; Schöning, M.J. Field-Effect Biosensors Modified with Tobacco Mosaic Virus Nanotubes as Enzyme Nanocarrier. Proceedings 2017, 1, 505.

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