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Proceedings 2017, 1(4), 494; doi:10.3390/proceedings1040494

Multimodal Neuroimaging Microtool for Infrared Optical Stimulation, Thermal Measurements and Recording of Neuronal Activity in the Deep Tissue

1
MTA EK NAP B Research Group for Implantable Microsystems, Budapest, Hungary
2
Doctoral School of Material Science & Technology, Óbuda University, Budapest, Hungary
3
Department of Atomic Physics, Budapest University of Technology & Economics, Budapest, Hungary
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 25 August 2017
Download PDF [570 KB, uploaded 26 August 2017]

Abstract

Infrared neural stimulation (INS) uses pulsed near-infrared light to generate highly controlled temperature transients in neurons, leading them to fire action potentials. Stimulation of the superficial layer of the intact brain has been presented, however, the stimulation of the deep neural tissue has larger potential in view of therapeutic use. To reveal the underlying mechanism of deep tissue stimulation properly, we present the design, the fabrication scheme and functional testing of a novel, multimodal microelectrode for future INS experiments. Three modalities—electrophysiological recording, thermal measurements and infrared waveguiding abil—were integrated based on silicon MEMS technology. Due to the advanced functionalities, a single probe is sufficient to determine safe stimulation parameters in vivo. As far as we know, this is the first multimodal microelectrode designed for INS studies in deep neural tissue. In this paper, the technology and results of chip-scale measurements are presented.
Keywords: infrared neural stimulation; optrode; silicon waveguide; neural probes infrared neural stimulation; optrode; silicon waveguide; neural probes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Horváth, Á.C.; Sepsi, Ö.; Boros, C.Ö.; Beleznai, S.; Koppa, P.; Fekete, Z. Multimodal Neuroimaging Microtool for Infrared Optical Stimulation, Thermal Measurements and Recording of Neuronal Activity in the Deep Tissue. Proceedings 2017, 1, 494.

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