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Proceedings 2017, 1(4), 289; doi:10.3390/proceedings1040289

Toward the Analysis of Mitochondria Isolated from Leukemic Cells with Electrochemically Instrumented Microwell Arrays

1
Laboratory for Analysis and Architecture of Systems (LAAS-CNRS), 31400 Toulouse, France
2
Cancer Research Center of Toulouse (CRCT-INSERM), Toulouse, France
3
L’Institut des Sciences Moléculaires (ISM-CNRS), Bordeaux, France
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 25 August 2017
(This article belongs to the Proceedings of Eurosensors 2017)
Download PDF [470 KB, uploaded 26 August 2017]

Abstract

This work deals with the development of electrochemical transducers for the analysis of the metabolic status of mitochondria isolated from leukemic cells. It proposes the use of ring nanoelectrodes (RNE) integrated into microwell arrays for the simultaneous monitoring of the oxygen (O2) consumption and the hydrogen peroxide (H2O2) production. The sensor enabled the real-time recording of the oxygen consumption of approximately 10,000 isolated mitochondria. Solutions are now proposed to detect H2O2 production and to reduce the number of mitochondria under test, targeting the single mitochondrion analysis.
Keywords: bioelectrochemical nanosensor; microwell arrays; isolated mitochondria; acute myeloid leukemia bioelectrochemical nanosensor; microwell arrays; isolated mitochondria; acute myeloid leukemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lemercier, G.; Sekli-Belaïdi, F.; Vajrala, S.; Descamps, E.; Foncy, J.; Arbault, S.; Sarry, J.-E.; Temple-Boyer, P.; Launay, J. Toward the Analysis of Mitochondria Isolated from Leukemic Cells with Electrochemically Instrumented Microwell Arrays. Proceedings 2017, 1, 289.

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