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Proceedings 2017, 1(10), 1074; doi:10.3390/proceedings1101074

Effect of Paclitaxel Loaded Chitosan Nanoparticles and Quantum Dots on Breast Cancer

1
Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey
2
Department of Pharmaceutical Technology, Faculty of Pharmacy, Biruni University, Topkapı 34010, İstanbul, Turkey
3
Department of Biology, Faculty of Science, Gazi University, Etiler 06330, Ankara, Turkey
4
Department of Molecular Biology and Genetics, Faculty of Science, Gazi University, Etiler 06330,Ankara, Turkey
5
Department of Pharmaceutical Technology, Faculty of Pharmacy, Biruni University, Topkapı 34010,İstanbul, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 13 November 2017
Download PDF [179 KB, uploaded 13 November 2017]

Abstract

The aim of the study was to investigate the effect of paclitaxel loaded nanocarrier systems (chitosan nanoparticles or quantum dots) on breast cancer. Paclitaxel loaded chitosan nanoparticles and quantum dots were prepared with the particle size of 153.6 nm and 302.8 nm respectively. The activities nanocarrier systems were determined using 7–12-dimethylbenzaantracene (DMBA)-induced breast cancer model in six-week-old female, nonpregnant, Wistar albino rats. Paclitaxel loaded nanocarrier systems were administered intraperitoneally to tumor bearing rats and their tumor volumes were measured. At the end of the experiment rats were sacrificed and their tissue sections were analyzed. Both nanocarrier systems (chitosan nanoparticles or quantum dots) successfully reduced the tumors size. This study provides some information about the preparation techniques of paclitaxel loaded nanocarriers and some possible alternatives or strategies for the treatment of breast cancer using these nanocarriers.
Keywords: Breast cancer; DMBA; paclitaxel; quantum dots; nanoparticles Breast cancer; DMBA; paclitaxel; quantum dots; nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Demir, G.M.; Ilhan, M.; Akkol, E.K.; Taştan, H.; Işık, A.; Değim, İ.T. Effect of Paclitaxel Loaded Chitosan Nanoparticles and Quantum Dots on Breast Cancer. Proceedings 2017, 1, 1074.

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