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Proceedings 2017, 1(10), 1067; doi:10.3390/proceedings1101067

Synthesis of Anthocyanin-Rich Red cabbage Nanoflowers and Their Antimicrobial and Cytotoxic Properties

1
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
2
Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
3
Department of Biology, Faculty of Science, Ankara University, Ankara 06560, Turkey
4
Biotechnology Institute, Ankara University, Ankara 06560, Turkey
5
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara 06560, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November, 2017.
*
Author to whom correspondence should be addressed.
Published: 15 November 2017
Download PDF [136 KB, uploaded 15 November 2017]

Abstract

In this report we developed, for the first time, a novel plant extract–metal ions nanoflower (NFs) and investigate their cytotoxic properties. The major anthocyanins (Anth) of Red cabbage, acted as organic component and metal ions, copper (II) (Cu2+) and silver ions (Ag+) acted as inorganic components. Although Anth-Cu2+ nanoflowers are quite compact, uniform and porous morphology, Anth-Ag+ nanoflower gives splayed shape. Scanning Electron Microscopy (SEM), Fourier Transform Infrared spectrometry (FT-IR) and Energy-Dispersive X-ray (EDX) spectroscopy and Powder X-ray Diffraction (PXRD) were used to examine the structrues of the NFs. The FT-IR results show Cu–O and Cu–N bonds in NF, can be indication of the NFs formation. While antimicrobial activities of the NFs were tested against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Candida albicans (ATCC 90028), cytotoxicity studies were performed with MCF7 cell line. The potential mechanisms of antimicrobial and cytotoxic effects of the NFs can be the negatively/positively charged molecules in the plant extracts, which may enhance reaction between the NFs and the cells and the action of the NFs as Fenton like agent for production of Cu+ and Ag+ ions and various radicals, which cause membrane damage and cell death through oxidative stress.
Keywords: anthocyanin; Red cabbage; nanoflower; antibacterial activity; cytotoxicity anthocyanin; Red cabbage; nanoflower; antibacterial activity; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Konca, S.F.; Tasdemir, D.; Aydogdu, G.; Yilmaz, E.; Bozkir, A.; Ocsoy, I. Synthesis of Anthocyanin-Rich Red cabbage Nanoflowers and Their Antimicrobial and Cytotoxic Properties. Proceedings 2017, 1, 1067.

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