Next Article in Journal
Effects of Fulvic Acid on Different Cancer Cell Lines
Previous Article in Journal
Antiproliferative Effect of Methanolic Extract of Linum arboreum on A549 Cells
Article Menu

Article Versions

Export Article

Open AccessAbstract
Proceedings 2017, 1(10), 1056; doi:10.3390/proceedings1101056

Cytotoxic Effects of Alchemilla mollis (Buser) Rothm. Extracts on MCF 7 Cell Line

1
Faculty of Pharmacy, Department of Pharmaceutical Botany, Erciyes University, Kayseri 38039, Turkey
2
Faculty of Pharmacy, Department of Pharmacognosy, Erciyes University, Kayseri 38039, Turkey
3
Faculty of Pharmacy, Department of Pharmacognosy, Eastern Mediterranean University, Gazimağusa,North Cyprus via Mersin 10, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 14 November 2017
Download PDF [155 KB, uploaded 14 November 2017]

Abstract

Alchemilla is a genus of herbaceous perennial plants in the Rosaceae, with the common name Lady’s Mantle. Aerial part of the plant which is used medicinally, traditionally used for skin irritations, wounds, female conditions such as menorrhagia, menopause and painful periods. Alchemilla mollis (Buser) Rothm. which grown in Black Sea Region of Turkey were investigated for its cytotoxic activities on MCF 7 cell line with SRB method A. mollis herb material was extracted with, methanol using a Soxhlet apparatus for 8 h. and separately A. mollis herb material was extracted with water using reflux for 3 h. Deodorized water extract of A. mollis was prepared using Clevenger apparatus. Results clearly demonstrated that the water extract of A. mollis has the highest cytotoxic effect among the other extracts. Water extract was significantly cytotoxic between the 62.5–1000 µg/mL concentrations (p < 0.05). The IC50 value of the water, deodorized water and methanol extracts are 59.34 ± 3.41 µg/mL, 87.37 ± 25.15 µg/mL, 68.18 ± 6.12 µg/mL, respectively. The cytotoxic activity on MCF7 cell line of the A. mollis was first studied by us and the results are promising. Further studies are needed to confirm in vivo anti-tumorgenicity and subsequent chemical characterization of the active molecule(s).
Keywords: Alchemilla mollis; cytotoxity; MCF 7 Alchemilla mollis; cytotoxity; MCF 7
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

İlgün, S.; Karatoprak, G.Ş.; Koşar, M. Cytotoxic Effects of Alchemilla mollis (Buser) Rothm. Extracts on MCF 7 Cell Line. Proceedings 2017, 1, 1056.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top