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Proceedings 2017, 1(10), 1040; doi:10.3390/proceedings1101040

Cytotoxic Activity of Endemic Astragalus argaeus Boiss. from Turkey

1
Biology Department, Science Faculty, Erciyes University, Kayseri 38039, Turkey
2
Graduate School Natural Applied Science, Erciyes University, Kayseri 38039, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 10 November 2017
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Abstract

Astragalus L. is the largest genus in the family Leguminosae with over 3000 species and is represented in Turkey by 445 species, of which 224 are endemic. Several Astragalus species have many biological properties such as hepatoprotective, immunostimulant, antiviral, anti-aging, antitumor, antioxidant, antimicrobial, antimalarial, antileshmanial, antiperspirant, anti-inflammatory, diuretic and tonic. The aim of this research was the investigation of the cytotoxic activities of extracts obtained from underground and aerial parts of Astragalus argaeus Boiss. on a human breast cancer cell line (MCF-7). The cytotoxic effects of extracts on MCF-7 (human breast cancer cell lines) and fibroblast cells during 24 and 48 h were determined by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphynyl tetrazolium bromide (MTT) assay. The extracts showed weak cytotoxic activity on MCF-7 during 24 h. To the best of our knowledge, this study is the first report on cytotoxic activity of A. argaeus.
Keywords: Astragalus argaeus; cytotoxic activity; MCF-7 Astragalus argaeus; cytotoxic activity; MCF-7
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Albayrak, S.; Kaya, O. Cytotoxic Activity of Endemic Astragalus argaeus Boiss. from Turkey. Proceedings 2017, 1, 1040.

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