Next Article in Journal
Apoptotic Effects of Mount Bulgar Viper (Montivipera bulgardaghica) PLA2 and SVMPs Venom Peptide fractions on HeLa and A549 Cancer Cells
Previous Article in Journal
“Arrivals”: Narrating Migration through Images. The Use of Images in Post-Traumatic Therapy
Article Menu

Article Versions

Export Article

Open AccessAbstract
Proceedings 2017, 1(10), 1029; doi:10.3390/proceedings1101029

Investigation of In Vitro Cytotoxic Effects of Montivipera xanthina on Healthy and Cancer Human Lung Cell Lines

Department of Biology, Science and Art Faculty, Uludag University, Bursa 16059, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 14 November 2017
Download PDF [142 KB, uploaded 14 November 2017]

Abstract

Biotoxins have been used for therapeutic purposes in many cultures since ancient times. It is known that from simple to more complex organisms the animal kingdom contain poisons. Works in the field of anti-cancer seems to concentrate especially on bees, spiders, scorpions and snake venoms. In the present study, it was aimed to investigate the in vitro cytotoxic effects of Montivipera xanthina on normal and cancer human lung cell lines. For this purpose the cytotoxic effects of venoms collected from both species were investigated using XTT and Clonogenic assay on A549 human lung cancer and Beas-2B human healthy bronchial epithelial cell lines. In cytotoxicity tests it has been determined that venoms of M. xanthina concentration dependently decreased the viability of both A549 and Beas-2B cells. As a result of the XTT test, the IC50 values of the M. xanthina venom on A549 and Beas-2B were calculated as 1553 μg/mL and 2156 μg/mL, respectively. In the clonogenic test, these values were determined as 2112 μg/mL and 2457 μg/mL for the A549 and Beas-2B cells, respectively.
Keywords: snake venom; anticancer; cytotoxicity snake venom; anticancer; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huriyet, H.; Cavas, T.; Vatan, O.; Cinkilic, N. Investigation of In Vitro Cytotoxic Effects of Montivipera xanthina on Healthy and Cancer Human Lung Cell Lines. Proceedings 2017, 1, 1029.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top