Next Article in Journal
Echinococcus Granulosus Infection in Two Free-Ranging Lumholtz’s Tree-Kangaroo (Dendrolagus lumholtzi) from the Atherton Tablelands, Queensland
Previous Article in Journal
First Aid and Pre-Hospital Management of Venomous Snakebites
Article Menu

Export Article

Open AccessCase Report
Trop. Med. Infect. Dis. 2018, 3(2), 46; https://doi.org/10.3390/tropicalmed3020046

Strongyloides stercoralis Hyperinfection in an HIV-Infected Patient Successfully Treated with Subcutaneous Ivermectin

1
Infectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy
2
Clinical Pharmacology Unit, ASST Sette Laghi, 21100 Varese, Italy
3
Laboratory of Medical Microbiology, ASST Sette Laghi, 21100 Varese, Italy
4
Intensive Care Unit, ASST Sette Laghi, 21100 Varese, Italy
5
Department of Oncology and Onco-Hematology, University of Milan, 20129 Milan, Italy
*
Author to whom correspondence should be addressed.
Received: 22 March 2018 / Revised: 19 April 2018 / Accepted: 22 April 2018 / Published: 27 April 2018
Full-Text   |   PDF [356 KB, uploaded 3 May 2018]   |  

Abstract

A 39-year-old Ethiopian HIV-positive man with peripheral T-cell lymphoma developed Strongyloides stercoralis hyperinfection. The patient was initially treated with oral ivermectin for three weeks without response, most likely due to malabsorption because of concomitant paralytic ileus. Given the persistence of larvae in the body fluids, the worsening respiratory status and clinical malabsorption, veterinary parenteral formulation of ivermectin was administered. The very high plasma concentration of ivermectin achieved in the patient after parenteral administration led to a rapid improvement in his clinical condition and rapid disappearance of the parasite from biological samples, without any adverse reaction. View Full-Text
Keywords: Strongyloides stercoralis; hyperinfection; HIV; parenteral ivermectin Strongyloides stercoralis; hyperinfection; HIV; parenteral ivermectin
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Grossi, P.A.; Lombardi, D.; Petrolo, A.; Rovelli, C.; Di Rosa, Z.; Perriccioli, G.; Rossi, A.; Minoja, G.; Scaglione, F.; Dalla Gasperina, D. Strongyloides stercoralis Hyperinfection in an HIV-Infected Patient Successfully Treated with Subcutaneous Ivermectin. Trop. Med. Infect. Dis. 2018, 3, 46.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Trop. Med. Infect. Dis. EISSN 2414-6366 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top