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Vision 2017, 1(1), 3; doi:10.3390/vision1010003

Multifocal Electroretinography in the Presence of Temporal and Spatial Correlations and Eye Movements

Department of Ophthalmology, and James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA 30912, USA
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Author to whom correspondence should be addressed.
Academic Editor: David E. Irwin
Received: 1 March 2016 / Revised: 18 April 2016 / Accepted: 3 May 2016 / Published: 9 May 2016
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Abstract

Releasing patients from the fixation task, and permitting them to view natural stimuli such as movies, would provide increased comfort, and potentially additional signs of retinal function, when recording multifocal electroretinograms (mfERGs). Techniques must be developed to handle the difficulties that arise from these alternative stimulation strategies. Multifocal stimuli were presented to volunteer human subjects with and without fixation. Retinocentric analyses were performed to deal with shifts of the stimulus across the retina in the presence of eye movements. Artificial scotomas that moved with the eyes to simulate local retinal defects were presented to assess whether such defects might be detectable in the presence of eye movements. Temporal and spatial correlations in the stimulus can be discounted, permitting retinal kernels to be measured in response to natural stimuli. Responses to temporally natural stimuli tend to have slightly stronger amplitudes because of the presence of low temporal frequencies in these stimuli. The effects of eye movement artifacts can be reduced, permitting similar kernels to be obtained in the absence and presence of eye movements. Convergence to stable kernels took slightly longer in the presence of temporal correlations or eye movements. Artificial scotomas can be localized with these methods. It may be possible to perform multifocal ERG recordings in the clinic using more flexible, natural techniques. However, work is needed to achieve results comparable to those routinely obtained with conventional methods. View Full-Text
Keywords: multifocal ERG; eye movements; decorrelation; retinal function; scotoma; kernel analysis multifocal ERG; eye movements; decorrelation; retinal function; scotoma; kernel analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Saul, A.B.; Still, A.E. Multifocal Electroretinography in the Presence of Temporal and Spatial Correlations and Eye Movements. Vision 2017, 1, 3.

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