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J. Funct. Morphol. Kinesiol. 2017, 2(4), 35; doi:10.3390/jfmk2040035

Exercise Training as Treatment of Nonalcoholic Fatty Liver Disease

1
Duke Integrative Medicine, Duke University Medical Center, Durham, NC 27705, USA
2
Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
3
School of Public Health, Brown University, Providence, RI 02903, USA
4
Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA
5
Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
6
Division of Gastroenterology & Hepatology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
*
Author to whom correspondence should be addressed.
Received: 5 September 2017 / Revised: 20 September 2017 / Accepted: 22 September 2017 / Published: 24 September 2017
(This article belongs to the Special Issue Tailored Exercise in Patients with Chronic Diseases 2017)
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Abstract

Nonalcoholic Fatty Liver Disease (NAFLD) is a growing health epidemic in developed countries with increased prevalence in obese and diabetic populations. Exercise is an established and essential component of lifestyle modification for NAFLD disease management. Despite numerous studies reporting exercise-mediated improvements in NAFLD, there remains a large gap in our knowledge of how to optimize exercise prescriptions and whether the benefits of exercise extend beyond improvements in liver fat. In this review, we summarize studies that have investigated the independent effects of exercise training on liver enzymes, hepatic fat, and histologic markers in NAFLD. Overall, 12-weeks of aerobic, resistance, the combination of aerobic and resistance, and novel training modalities, including acceleration and hybrid training, significantly improve liver enzymes and hepatic fat. The greatest benefits in NAFLD may occur through the combination of aerobic and resistance training that targets both cardiorespiratory fitness, and mediators of skeletal muscle, known as myokines. Understanding the role of myokines in the beneficial effects of exercise in NAFLD may identify future therapeutic targets that can be modified with tailored exercise prescriptions. View Full-Text
Keywords: exercise; NAFLD; NASH; aerobic; resistance; training exercise; NAFLD; NASH; aerobic; resistance; training
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Glass, O.K.; Radia, A.; Kraus, W.E.; Abdelmalek, M.F. Exercise Training as Treatment of Nonalcoholic Fatty Liver Disease. J. Funct. Morphol. Kinesiol. 2017, 2, 35.

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J. Funct. Morphol. Kinesiol. EISSN 2411-5142 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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