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Methods Protoc. 2018, 1(2), 23; https://doi.org/10.3390/mps1020023

Ionic Liquid-Assisted Laser Desorption/Ionization–Mass Spectrometry: Matrices, Microextraction, and Separation

Department of Chemistry, Assuit University, Assuit 71515, Egypt
Received: 12 April 2018 / Revised: 13 June 2018 / Accepted: 15 June 2018 / Published: 19 June 2018
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Abstract

Ionic liquids (ILs) have advanced a variety of applications, including matrix-assisted laser desorption/ionization–mass spectrometry (MALDI–MS). ILs can be used as matrices and solvents for analyte extraction and separation prior to analysis using laser desorption/ionization–mass spectrometry (LDI–MS). Most ILs show high stability with negligible sublimation under vacuum, provide high ionization efficiency, can be used for qualitative and quantitative analyses with and without internal standards, show high reproducibility, form homogenous spots during sampling, and offer high solvation efficiency for a wide range of analytes. Ionic liquids can be used as solvents and pseudo-stationary phases for extraction and separation of a wide range of analytes, including proteins, peptides, lipids, carbohydrates, pathogenic bacteria, and small molecules. This review article summarizes the recent advances of ILs applications using MALDI–MS. The applications of ILs as matrices, solvents, and pseudo-stationary phases, are also reviewed. View Full-Text
Keywords: ionic liquids; matrix-assisted laser desorption/ionization–mass spectrometry; extraction; separation; ionic liquid matrices ionic liquids; matrix-assisted laser desorption/ionization–mass spectrometry; extraction; separation; ionic liquid matrices
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Abdelhamid, H.N. Ionic Liquid-Assisted Laser Desorption/Ionization–Mass Spectrometry: Matrices, Microextraction, and Separation. Methods Protoc. 2018, 1, 23.

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