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Int. J. Neonatal Screen. 2018, 4(2), 20; https://doi.org/10.3390/ijns4020020

Potential Benefit of Selective CMV Testing after Failed Newborn Hearing Screening

1
Section Phoniatrics and Pediatric Audiology, Department of Otolaryngology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
2
Department of Otolaryngology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
*
Author to whom correspondence should be addressed.
Received: 23 May 2018 / Revised: 13 June 2018 / Accepted: 19 June 2018 / Published: 19 June 2018
(This article belongs to the Special Issue Newborn Hearing Screening)
View Full-Text   |   Download PDF [247 KB, uploaded 19 June 2018]

Abstract

Evidence-based guidelines for the prevention, diagnosis and treatment of congenital cytomegalovirus (cCMV) were recently released by two independent expert groups. Of particular emphasis was the relationship between cCMV and sensorineural hearing loss (SNHL), a major component of the virus’ overall disease burden. In this study, a literature review was performed to estimate the proportion of cCMV-related SNHL cases, which might be identified through selective cCMV testing following failed newborn hearing screening. Furthermore, it was of interest to estimate the potential benefit of emerging antiviral therapies. Currently, at most 10% of cCMV-related SNHL is likely to be identified clinically. Through use of a selective cCMV testing protocol, however, a significant improvement in the identification rate can be achieved. Recent expert group statements strongly recommend antiviral therapy in cases of moderate-to-severe disease, especially in the presence of central nervous system involvement. Though differences exist between recommendations in instances of isolated SNHL or SNHL in combination with only mild symptoms, the majority of experts in both groups offered at least a weak recommendation for antiviral treatment. Available results suggest antiviral treatment could therefore benefit a meaningful proportion of newborns referred for cCMV testing following failed newborn hearing screening. View Full-Text
Keywords: congenital cytomegalovirus; sensorineural hearing loss; newborn hearing screening congenital cytomegalovirus; sensorineural hearing loss; newborn hearing screening
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Kummer, P.; Marcrum, S.C. Potential Benefit of Selective CMV Testing after Failed Newborn Hearing Screening. Int. J. Neonatal Screen. 2018, 4, 20.

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