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Biomimetics 2017, 2(4), 24; doi:10.3390/biomimetics2040024

EDTA and NTA Effectively Tune the Mineralization of Calcium Phosphate from Bulk Aqueous Solution

1
Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany
2
Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
3
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Universitat Politècnica de Catalunya, Avinguda d’ Eduard Maristany 10-14, 08019 Barcelona, Spain
4
Barcelona Research Centre in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, 08019 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Ille C. Gebeshuber
Received: 15 September 2017 / Revised: 23 November 2017 / Accepted: 30 November 2017 / Published: 13 December 2017
(This article belongs to the Special Issue Biomimetic Nanotechnology)
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Abstract

This study describes the effects of nitrilotriacetic acid (NTA) and ethylenediaminotetraacetic acid (EDTA) on the mineralization of calcium phosphate from bulk aqueous solution. Mineralization was performed between pH 6 and 9 and with NTA or EDTA concentrations of 0, 5, 10, and 15 mM. X-ray diffraction and infrared spectroscopy show that at low pH, mainly brushite precipitates and at higher pH, mostly hydroxyapatite forms. Both additives alter the morphology of the precipitates. Without additive, brushite precipitates as large plates. With NTA, the morphology changes to an unusual rod-like shape. With EDTA, the edges of the particles are rounded and disk-like particles form. Conductivity and pH measurements suggest that the final products form through several intermediate steps. View Full-Text
Keywords: biomineralization; biomimetic mineralization; calcium phosphate; NTA; EDTA; precipitation; brushite; hydroxyapatite biomineralization; biomimetic mineralization; calcium phosphate; NTA; EDTA; precipitation; brushite; hydroxyapatite
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hentrich, D.; Tauer, K.; Espanol, M.; Ginebra, M.-P.; Taubert, A. EDTA and NTA Effectively Tune the Mineralization of Calcium Phosphate from Bulk Aqueous Solution. Biomimetics 2017, 2, 24.

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